Results 41 to 50 of about 82,858 (250)

Effects of Four Exogenous Substances on the Content of Stone Cells in Fragrant Pear in Relation to Its Quality [PDF]

open access: yesShipin Kexue
Objective: To find the best way to reduce the content of stone cells in fragrant pear fruit. Methods: Seven to eight-year-old fragrant pear trees were chosen for foliar application with exogeneous substances including calcium chloride, zinc chloride ...
MA Ling, AN Shijie, LI Tianle, YAN Pan, DENG Yonghui, CHEN Qiling
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Microbiologically induced aesthetic and structural changes to dimension stone

open access: yesnpj Materials Degradation, 2021
Dimension stone is natural rock prepared for building use. It is rapidly colonised by microorganisms that cause discoloration (mainly cyanobacteria, algae and fungi) and structural damage.
Christine C. Gaylarde   +1 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

The Dual Role of Lignin in Fruit Trees: Unraveling Regulatory Networks from Stress Resilience to Quality Control

open access: yesPlants
Lignin deposition in fruit trees represents a fundamental physiological trade-off: essential for structural integrity and stress adaptation, yet excessive or mistimed activation compromises fruit texture, palatability, and market value.
Yun Shao   +4 more
doaj   +1 more source

Distribution of stone cell in Asian, Chinese, and European pear fruit and its morphological changes

open access: yesJournal of Applied Botany and Food Quality, 2013
This study was conducted to microscopically verify the distribution and morphological changes occurring in stone cells during fruit growth in order to determine physiological changes occurring in stone cells in pear fruits. European pear (P.
Jin-Ho Choi, Sang-Hyun Lee
doaj   +1 more source

Flexible Ureterorenoscopy and Laser Lithotripsy in a Patient with a Stone in the Transplanted Kidney: A Case Report

open access: yesActa Clinica Croatica, 2023
We report a case of a 31-year-old patient with obstructive ureterolithiasis in a transplanted kidney, treated endoscopically with flexible ureterorenoscopy and laser lithotripsy.
Marjan Marić   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

THE INSIDENCE OF BLADDER SQUAMOUS CELL CARCINOMA IN LARGE BLADDER STONE CASES

open access: yesJurnal Urologi Indonesia, 2015
Objective: To determine the incidence of squamous cell carcinoma (SCC) in patients with large bladder stone (> 40 mm). Material & method: This is a descriptive retrospective cross-sectional study, data was collected from medical record on patients with a
Joko Pitoyo, Ferry Safriadi
doaj   +1 more source

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