Results 171 to 180 of about 3,408,578 (301)

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Getting a Handle on Technological Complexity in the Acheulean: Hand-axes Make Excellent High-Energy Hafted Woodworking Tools

EXARC Journal
Reconstructing human behavioural complexity from stone tools is a primary concern for the Palaeolithic archaeologist. Two nested challenges exist in this reconstruction.
Christopher Scott, Karl Lee
doaj  

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

George W. Stone Civil War letters [DIGITAL CONTENT]

This collection contains three letters written by George W.
Stone, George W., 1836-?
core  

High Upper Critical Field and Type II Superconductivity in Epitaxial Cubic W2N Thin Films

Advanced Science, EarlyView.
Superconducting thin films of stoichiometric W2N demonstrate a high upper critical field (Hc2) of ∼ 8.5 T, uncommon among binary transition metal nitrides. This robust superconducting response under high magnetic fields highlights the technological relevance of W2N for superconducting applications, e.g., integrated quantum and cryogenic electronics ...
Aditya Singh, Arnaud le Febvrier, Sanath Kumar Honnali, Abhisek Mishra, Grzegorz Greczynski, Subhankar Bedanta, Per Eklund, Ajay Soni   +7 more
wiley   +1 more source

Wild capuchin monkeys adjust stone tools according to changing nut properties. [PDF]

Sci Rep, 2016
Luncz LV, Falótico T, Pascual-Garrido A, Corat C, Mosley H, Haslam M.   +5 more
europepmc   +1 more source

Geological Specimens and Stone Tools

5 x 4 glass plate, five rocks on a piece of fabric92 H86-037 Lester Black Collection Vault 1-112 Box 1 of 8 Glass plates H86-037 Lester Black Collection Pierre Misc. Pierre and Black relatives 92 stone tools
Black, Lester
core  

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Teaching to make stone tools: new experimental evidence supporting a technological hypothesis for the origins of language. [PDF]

Sci Rep, 2017
Lombao D, Guardiola M, Mosquera M.
europepmc   +1 more source