Results 31 to 40 of about 3,408,578 (301)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Data For: “Stone Tools in Upper Norrland: A Study of Stone Tools in Norrbottens County, Sweden”

Journal of Open Archaeology Data
Much of the archived stone tool material found in Northern Sweden are stray finds not tied to an extensively documented archaeological site. This situation has led to artifacts seldom being revisited after being deposited in an archive. As a result, many
Love Eriksson, Michael A. Monzón
doaj   +1 more source

A Comparative Analysis of Wood Residues on Experimental Stone Tools and Early Stone Age Artifacts: A Koobi Fora Case Study [PDF]

, 2002
There have been recently reported plant residues on stone tools from the Okote Member, Koobi Fora, Kenya. No comparative microscopy, however, was available for more specific identification of the residues.
Herrygers, Christa
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stone Tools Continuity of the Late Mesolithic and Early Neolithic Population of the Lower Kama River Region

Поволжская археология, 2013
A widespread thesis concerning population continuity in the Lower Kama region during the Late Mesolithic and the Early Neolithic is challenged in the article.
Viskalin Aleksandr V.
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Insights into the cognitive evolution of genus Homo: Eye-tracking analysis of stone tool recognition in trained versus novice modern humans

Current Research in Behavioral Sciences
Eye tracking technologies have recently been used to analyze the visual exploration of stone tool stimuli by modern humans to investigate the cognition of our ancestors.
Chloé Bryche, Giovanni Federico, Arthur Seye, Arnaud Fournel, François Osiurak   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Earliest evidence for ground-edge axes: 35,400±410 cal BP from Jawoyn Country, Arnhem Land [PDF]

, 2010
Evidence for the world’s earliest stone tools dates to 3.4 million years ago and pre-dates the earliest known Homo species in eastern Africa. However ground-edged tools did not appear until the dispersal of cognitively fully modern Homo sapiens sapiens ...
David, Bruno, David, Bruno O., Whear, Ray, Delannoy, Jean-Jacques, Plisson, Hugues, Clarkson, Chris, Geneste, Jean-Michel, Petchey, Fiona   +7 more
core   +1 more source