Results 211 to 220 of about 270,897 (278)

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

De novo TANC2 stop‐loss variant associated with developmental impairment and drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Matthew A. Hintermayer, Kenneth A. Myers
wiley   +1 more source

A single nucleotide substitution introducing premature stop codon within CsTFL1 explains the determinate-2 phenotype in cucumber (Cucumis sativus L.). [PDF]

Sci Rep
Biernacik B, Słomnicka R, Kaźmińska K, Mużacz S, Bartoszewski G.   +4 more
europepmc   +1 more source

The oxygen‐sensing FixLJ represses nitrogen fixation in Rhodopseudomonas palustris in response to oxygen

mLife, EarlyView.
Abstract Biological nitrogen fixation in symbiotic diazotrophs is subject to oxygen regulation by an oxygen‐sensing FixLJ two‐component system under micro‐oxic conditions. However, it remains unclear whether this mechanism is conserved in free‐living diazotrophs.
Lingwei Cui, Yan Zeng, Mengmei Wang, Lu Huang, Zheyi Wang, Ying Liu, Yanning Zheng   +6 more
wiley   +1 more source

Polyaminated, acetylated and stop codon readthrough of recombinant Francisella tularensis universal stress protein in Escherichia coli. [PDF]

PLoS One
Girardo B, Schopfer LM, Yue Y, Lockridge O, Larson MA.   +4 more
europepmc   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Thirty years of glyphosate‐resistant crops and weeds: Current situation and future prospects

Pest Management Science, EarlyView.
Since 1996, when the first glyphosate‐resistant crop was commercialized and the first resistant weed was reported, resistance has expanded globally. This review analyzes emergence patterns across weed species, crops, regions, resistance mechanisms, and herbicides.
Ricardo Alcántara‐de la Cruz, Yure Marin Guidi, Mariana Ramirez‐Castillo, Fernando Storniolo Adegas, Caio Antonio Carbonari, Edivaldo Domingues Velini, Rafael De Prado, Stephen O. Duke   +7 more
wiley   +1 more source

Stop-Codon–Mediated Polycistronic Translation Enables Multi-ORF Expression in Mammalian Neurons In Vivo

Olszakier S, Heinrich R, Andreyanov M, Wessal H, Berlin S.   +4 more
europepmc   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

A revised genome annotation of the model cyanobacterium Synechocystis based on start and stop codon-enriched ribosome profiling and proteogenomics

Hess W, Krauspe V, Reimann V, Minges P, Bilger R, Gerstner M, Gelhausen R, Backofen R, Heiniger B, Jaques G, Ahrens C, Spät P, Macek B, Sharma C, Hadjeras L.   +14 more
europepmc   +1 more source