Results 1 to 10 of about 69,133 (285)
Bioresources and Bioprocessing, 2022 Terminators serve as the regulatory role in gene transcription termination; however, few researches about terminator optimization have been conducted, which leads to the lack of available and universal terminator for gene expression regulation in ...
Yi Rao +9 more
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Incoherent dual regulation by a SAM-II riboswitch controlling translation at a distance
RNA Biology, 2022 In Sinorhizobium meliloti, the methionine biosynthesis genes metA and metZ are preceded by S-adenosyl-L-methionine (SAM) riboswitches of the SAM-II class. Upon SAM binding, structural changes in the metZ riboswitch were predicted to cause transcriptional
Robina Scheuer +5 more
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Synthetic refactor of essential genes decodes functionally constrained sequences in yeast genome
iScience, 2022 Summary: The relationship between gene sequence and function matters for fundamental and practical reasons. Here, yeast essential genes were systematically refactored to identify invariable sequences in the coding and regulatory regions.
Zhenzhen Liang +13 more
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Designing and constructing the encoding cassette of human epidermal growth factor for expression in barley seeds [PDF]
مجله بیوتکنولوژی کشاورزی, 2021 Objective Plants are very efficient in producing valuable pharmaceutical proteins. Human epidermal growth factor (hEGF) has numerous effects on various cellular systems, including wound healing, organogenesis, and so on. The present study was carried out
Shahrokh Garousi +5 more
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Translational termination without a stop codon [PDF]
Science, 2016 Rescuing stalled ribosomes A small percentage of bacterial mRNAs lack a stop codon. Ribosomes stall at the end of such mRNAs, and the buildup of stalled ribosomes can be lethal. The primary rescue mechanism, in which translation continues on a piece of RNA that contains a stop codon, is a drug target.
Nathan R, James +3 more
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Ataluren—Promising Therapeutic Premature Termination Codon Readthrough Frontrunner [PDF]
Pharmaceuticals, 2021 Around 12% of hereditary disease-causing mutations are in-frame nonsense mutations. The expression of genes containing nonsense mutations potentially leads to the production of truncated proteins with residual or virtually no function. However, the translation of transcripts containing premature stop codons resulting in full-length protein expression ...
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Premature Termination Codon: A Tunable Protein Translation Approach
BioTechniques, 2022 Cellular protein-protein interactions are largely dependent on the activities of signaling proteins. Here, we present a technique to tune gene expression at translation level based on G418-inducible readthrough premature termination codon (PTC-on).
Xiyao Cheng +6 more
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A Novel Mutation of PARK-2 Gene in a Patient with Early-onset Parkinson’s Disease
Oman Medical Journal, 2020 Between 3–5% of all patients with Parkinson’s disease (PD) have onset before the age of 40 years, which is likely related to genetic causes. Parkin gene mutations are the most common mutations, which are associated with autosomal recessive early-onset PD.
Tariq Alafifi +4 more
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Rous Sarcoma Virus RNA Stability Element Inhibits Deadenylation of mRNAs with Long 3′UTRs
Viruses, 2017 All retroviruses use their full-length primary transcript as the major mRNA for Group-specific antigen (Gag) capsid proteins. This results in a long 3′ untranslated region (UTR) downstream of the termination codon. In the case of Rous sarcoma virus (RSV),
Vidya Balagopal, Karen L. Beemon
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BMC Pediatrics, 2021 Background Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is a rare autosomal recessive lysosomal storage disorder. Up to now, reports on the clinical characteristics of MPS IVA mainly focused on patients with progressive bone dysplasia and ...
Zhuhui Ge +6 more
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