Results 41 to 50 of about 69,133 (285)

Chain termination codons and polymerase‐induced frameshift mutations

FEBS Letters, 1997
The consensus sequence for single‐base deletions in non‐reiterated runs during in vitro DNA‐dependent DNA polymerisation is refined using data available in the literature. This leads to the observation that chain termination codons are hotspots for single‐base deletions.
Jestin, Jean-Luc, Kempf, Achim
openaire   +2 more sources

ps2, the gene responsible for functional sterility in tomato, due to non-dehiscent anthers, is the result of a mutation in a novel polygalacturonase gene [PDF]

, 2009
The recessive mutation ps-2, which appeared spontaneously in tomato, confers functional male sterility due to non-dehiscent anthers. In this study, we isolated and characterized the PS-2 gene.
Gorguet, B.J.M., Heusden, A.W., van, Lammeren, A.A.M., van, Schipper, E.H., Visser, R.G.F.   +4 more
core   +2 more sources

Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides

eLife, 2019
AbstractStop codon readthrough (SCR) occurs when the ribosome miscodes at a stop codon. Such readthrough events can be therapeutically desirable when a premature termination codon (PTC) is found in a critical gene. To study SCR in vivo in a genome-wide manner, we treated mammalian cells with aminoglycosides and performed ribosome profiling.
Jamie R Wangen, Rachel Green
openaire   +3 more sources

Pharmaceuticals Promoting Premature Termination Codon Readthrough: Progress in Development

Biomolecules, 2023
Around 11% of all known gene lesions causing human genetic diseases are nonsense mutations that introduce a premature stop codon (PTC) into the protein-coding gene sequence. Drug-induced PTC readthrough is a promising therapeutic strategy for treating hereditary diseases caused by nonsense mutations.
Shan Li, Juan Li, Wenjing Shi, Ziyan Nie, Shasha Zhang, Fengdie Ma, Jun Hu, Jianjun Chen, Peiqiang Li, Xiaodong Xie   +9 more
openaire   +3 more sources

Prevalence and Implications of Plasmodium Falciparum Multidrug Resistance Gene Mutations (PFMDR1) Among Pediatric Patients with Malaria in Kano, Nigeria

UMYU Journal of Microbiology Research
A genetic indicator of the parasites' vulnerability to anti-malarial medications is the Plasmodium falciparum multidrug resistance gene 1 (pfmdr1). In this study, malaria patients aged 0–14 who were treated at Murtala Muhammad Specialist Hospital in Kano,
Ummukulsum Mustapha, Ado Shehu, Yunusa Ahmad, Usman Sanusi Usman, Yusuf Abdu Misau, Attahir Sa’ad Ayuba, Aliyu Muhammad Maigoro, Abdullahi Haruna Ibrahim, Haddad Mahfuz Muhammad, Fatima Zubairu Yakubu   +9 more
doaj   +3 more sources

CD8+ T cell memory is sustained in mice by hepatic stellate cells

Hepatology, EarlyView., 2022
HSC role in memory CD8+ T cell maintenance. Abstract Background and Aims Long‐lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8+ cytotoxic T cells (MemCD8TCs) is thought to be mediated by IL‐15/IL‐15R heterodimer (15HD)‐expressing myeloid cells.
Yi‐Ting Chen, Yu‐Chia Su, Yee‐Ern Or, Chin‐Fu Cheng, John T. Kung   +4 more
wiley   +1 more source

CRISPR/Cas9-mediated mutagenesis of phytoene desaturase in diploid and octoploid strawberry

Plant Methods, 2019
Background Gene editing using CRISPR/Cas9 is a simple and powerful tool for elucidating genetic controls and for crop improvement and its use has been reported in a growing number of important food crops, including recently Fragaria.
Fiona M. Wilson, Kate Harrison, Andrew D. Armitage, Andrew J. Simkin, Richard J. Harrison   +4 more
doaj   +1 more source

Rule-based Modeling of Transcriptional Attenuation at the Tryptophan Operon [PDF]

, 2009
Transcriptional attenuation at E.coli\u27s tryptophan operon is a prime example of RNA-mediated gene regulation. In this paper, we present a discrete stochastic model for this phenomenon based on chemical reactions. Our model is compact and intelligible,
, , Nebut, Mirabelle
core   +1 more source

Mitochondrial genome sequencing and evolutionary analysis of geoduck clam Panopea japonica

Aquaculture and Fisheries
Geoduck clam (Panopea japonica), a large burrowing bivalve species, is primarily distributed in the Yellow Sea and Bohai Sea of China, Korean coastal waters, and marine areas near Hokkaido, Japan.
Jiaxin Xiao, Wen Zhao, Jiaxi Li, Jianbao Guo, Zhiying Gao, Yang Liu, Lei Fang, Zhongming Huo   +7 more
doaj   +1 more source

Isolation and Expression Analysis of the Ethylene Receptor Gene MiETR1b in Mango (Mangifera indica)

Horticultural Plant Journal, 2016
A mango ETHYLENE RESPONSE1 (ETR1) gene, designated MiETR1b, was isolated from the cotyledon of mango (Mangifera indica L. ‘Zihua’) using RT-PCR, and the 5′ and 3′ rapid amplification of cDNA ends.
Yunhe Li, Zhi Zhang, Qingsong Wu
doaj   +1 more source