A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa +7 more
wiley +1 more source
Remifentanil to Maintain Unresponsiveness While Propofol Concentrations Decline Before Emergence in Two Patients With Prior Emergence Agitation. [PDF]
Swenson JD +4 more
europepmc +1 more source
Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger +5 more
wiley +1 more source
The Gittins Index for a Transparent One-Armed Bandit with a Continuous Payoff Spectrum in Equilibrium States. [PDF]
Makowski M +2 more
europepmc +1 more source
Ultra‐Thin Tow‐Based Discontinuous Composites—Material Overview and Aspirations
Tow‐based discontinuous composites made from ultra‐thin tapes offer outstanding in‐plane mechanical properties. This material, inspired by Nacre, has high volume fraction of tapes exceeding 90 % and allows for quasi‐isotropic material plates less than 100 micrometer in thickness.
Ioannis Katsivalis +8 more
wiley +1 more source
Patient Attitudes and Factors Associated with Willingness to Deprescribe Prescribed Medications in Western Saudi Arabia: A Cross-Sectional Study. [PDF]
Alharthi MS +8 more
europepmc +1 more source
Recyclable Lignin‐Based Thermadapt Shape Memory Polymers With Near‐Infrared Light Response
ABSTRACT Covalent adaptable networks (CANs) have been designed to address the recycling challenges associated with thermosets, while preserving their mechanical properties. However, producing biobased CANs with intelligent response capabilities remains challenging.
Jian Liu +8 more
wiley +1 more source
Cancer control after pausing treatment with larotrectinib in responding children with sarcoma and a TRK fusion: a plain language summary. [PDF]
Mascarenhas L +7 more
europepmc +1 more source
Cuttlefish and squid can catch their prey within milliseconds using specialized tentacles and suckers. The physics of how the suckers can attach so quickly has remained a mystery given the technical challenges of studying them in vivo. In this publication, we develop a hydrogel that retains imprints of the suckers in order to estimate the forces they ...
Alexander Koehnsen +4 more
wiley +1 more source

