Results 91 to 100 of about 384,701 (284)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A Dynamic Offloading Strategy Based on Optimal Stopping Theory in Vehicle-to-Vehicle Communication Scenarios

Future Internet
Faced with the access of a large number of devices, and for mobile vehicles with high speeds, some situations may be far from the communication range of the current edge node, resulting in a significant increase in communication latency and energy ...
An Li, Jiaxuan Ling, Yeqiang Zheng, Mingliang Chen, Gaocai Wang   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Local Field Correction Effect on Dicluster Stopping Power in a Strongly Coupled Two-Dimensional Electron Gas System [PDF]

Journal of Sciences, Islamic Republic of Iran, 2013
We calculate the stopping power for heavy-ion diclusters moving in a strongly coupled two-dimensional electron gas system by using the local field corrected dielectric function at finite temperature.
T. Vazifehshenas, S. Saberi-Pouya
doaj  

Early stopping and non-parametric regression: An optimal data-dependent stopping rule

, 2013
The strategy of early stopping is a regularization technique based on choosing a stopping time for an iterative algorithm. Focusing on non-parametric regression in a reproducing kernel Hilbert space, we analyze the early stopping strategy for a form of ...
Raskutti, Garvesh, Wainwright, Martin J., Yu, Bin   +2 more
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Theoretical Study of Energy Loss of Proton in Human Tissues

Ibn Al-Haitham Journal for Pure and Applied Sciences
        In this paper, a theoretical study was carried out to calculate the proton energy loss in human tissues (Adipose tissue, Blood, Bone (Compact), Bone (Cortical), Brain, Eye lens, Lung, Skin, and Testicles) within the energy range of 1 MeV to 1000
Musaab I. Mohammed
doaj   +1 more source

The Bayes Lepski's Method and Credible Bands through Volume of Tubular Neighborhoods

, 2017
For a general class of priors based on random series basis expansion, we develop the Bayes Lepski's method to estimate unknown regression function. In this approach, the series truncation point is determined based on a stopping rule that balances the ...
van der Vaart, Aad W., Yoo, William Weimin   +1 more
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

An optimal multiple stopping rule–based cooperative downloading scheme in vehicular cyber-physical systems

International Journal of Distributed Sensor Networks, 2017
In vehicular cyber-physical systems, vehicular users are the edge nodes which are far away from the network core. Content accessing and downloading for vehicular users are expected to heavily rely on the deployment of RoadSide Units in vehicular cyber ...
Tao Jing, Cheng Zeng, Jin Qian, Zhen Li, Yan Huo   +4 more
doaj   +1 more source