Results 71 to 80 of about 5,120,600 (306)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Applied SciencesThe section span of the withdrawal space of fully mechanized top coal caving in an extra-thick coal seam is large, and with the gradual withdrawal of the hydraulic support, a series of strong dynamic pressure disasters occur in the withdrawal space, and ...
Dongdong Chen +8 more
doaj +1 more source
Integrated Optimization of Train Stop Planning and Scheduling on Metro Lines With Express/Local Mode
IEEE Access, 2019 Train stopping patterns and schedules play critical roles in the service design of metro lines with express/local mode. Previous studies on express/local mode generally handle the design of train stopping patterns and schedules independently, which ...
Zhujun Li, Baohua Mao, Yun Bai, Yao Chen
doaj +1 more source
Group Sequential Designs Applied in Psychological Research
Methodology, 2020 Psychological research is confronted with ever-increasing demands to save resources such as time and money while assuring high ethical standards. In medical and pharmaceutical research, group sequential designs have fundamentally changed traditional ...
Klemens Weigl, Ivo Ponocny
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The practice of going helps children to stop:The importance of context monitoring in inhibitory control [PDF]
, 2014 How do we stop ourselves during ongoing action? Recent work implies that stopping per se is easy given sufficient monitoring of contextual cues signaling the need to change action.
Chevalier, Nicolas +2 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Intranasal Therapy to Stop Status Epilepticus in Prehospital Settings [PDF]
Drugs in R&D, 2017 Status epilepticus (SE) is a medical emergency characterized by uncontrolled, prolonged seizures with rapid and widespread neuronal damage. Patients that suffer from longer episodes of SE are more likely to have poorer clinical outcomes and a higher cost of healthcare.
Benfield, John, Musto, Alberto
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
BMC Pediatrics, 2009 Background Decisions about interim analysis and early stopping of clinical trials, as based on recommendations of Data Monitoring Committees (DMCs), have far reaching consequences for the scientific validity and clinical impact of a trial. Our aim was to
van der Lee Johanna H +2 more
doaj +1 more source