Results 81 to 90 of about 5,120,600 (306)

Stopping and set-indexed local martingales

open access: yesStochastic Processes and their Applications, 1995
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ivanoff, B.Gail, Merzbach, Ely
openaire   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

On Infinite Horizon Optimal Stopping of General Random Walk [PDF]

open access: yes
The objective of this study is to provide an alternative characterization of the optimal value function of a certain Black- Scholes-type optimal stopping problem where the underlying stochastic process is a general random walk, i.e.
Jukka Lempa
core  

Modelling busway operation with mixed stopping and non-stopping buses [PDF]

open access: yes, 2015
This thesis investigated the complexity of busway operation with stopping and non-stopping buses using field data and microscopic simulation modelling.\ud \ud The proposed approach made significant recommendations to transit authorities to achieve the ...
Widana Pathiranage, Amila Gayan Rakkitha Thilakarathne
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

On an Effective Solution of the Optimal Stopping Problem for Random Walks [PDF]

open access: yes
We find a solution of the optimal stopping problem for the case when a reward function is an integer function of a random walk on an infinite time interval. It is shown that an optimal stopping time is a first crossing time through a level defined as the
Albert Shiryaev, Alexander Novikov
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Real-Time Runway Detection for Infrared Aerial Image Using Synthetic Vision and an ROI Based Level Set Method

open access: yesRemote Sensing, 2018
We present a new method for real-time runway detection embedded in synthetic vision and an ROI (Region of Interest) based level set method. A virtual runway from synthetic vision provides a rough region of an infrared runway.
Changjiang Liu, Irene Cheng, Anup Basu
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

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