Results 51 to 60 of about 223,857 (311)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Some aspects of statistical causality

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica
Causal thinking is deeply embedded in scientific understanding of the problems of applied statistics. This can not always be done by experiments and the researcher is restricted to observing the system he wants to describe.
Petrović Ljiljana
doaj   +1 more source

Furstenberg Topology and Collatz Problem

Axioms
The aims of this paper are two-fold. First, we present the result of the decomposition on the iterations of a Collatz transform into arithmetic sequences.
Edward Tutaj, Halszka Tutaj-Gasinska
doaj   +1 more source

Non-inertial stopping characteristics of a prototype pump

Advances in Mechanical Engineering, 2019
The characteristics of centrifugal pump in non-inertial stopping period have not been studied better by far. In this article, the variation characteristics of transient performance of a prototype pump are clarified experimentally in five non-inertial ...
Yu-Liang Zhang, Zu-Chao Zhu, Wen-Guang Li, Xiao-Qi Jia   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

How Long Does It Take to Stop? Are Children Able to Stop on Demand?

Applied Sciences
Children’s physical and cognitive development plays a crucial role in their ability to react appropriately in dynamic traffic situations. One key aspect of traffic safety is the ability to stop movement quickly and accurately after receiving a stop ...
Ernst Tomasch, Heinz Hoschopf, Bernd Schneider, Bettina Schützhofer, Martin Söllner, Barbara Krammer-Kritzer, Michael Plank, Hannes Glaser   +7 more
doaj   +1 more source

Influence of key factors on vehicle braking

Taikomieji Moksliniai Tyrimai, 2022
The article analyzes the influence of the driver's reaction time, the speed of the car's movement and the road surface on the length of the car's stopping and stopping distance.
Lukas Velykis, Jonas Skiauteris
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Density functional theory to study stopping power of proton in water, lung, bladder, and intestine

Open Engineering
Stopping power, range, and time of proton in water, lung, bladder, and intestinal human tissues are calculated using density functional theory and Beth’s relativistic equation in range of proton energy (0.01–1,000 MeV).
Jasim Wejdan A., Kadhim Rashid O.
doaj   +1 more source