Results 61 to 70 of about 3,753,682 (301)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The Optimal Stopping Problem of Dupuis and Wang: A Generalization [PDF]
In this paper, we study the optimal stopping problem of Dupuis and Wang analyzed in [7]. In this problem, the underlying follows a linear diffusion but the decision maker is not allowed to stop at any time she desires but rather on the jump times of an ...
Jukka Lempa
core
On simple representations of stopping times and stopping time sigma-algebras [PDF]
Statistics & Probability Letters, 2013 Abstract There exists a simple, didactically useful one-to-one relationship between stopping times and adapted cadlag (RCLL) processes that are non-increasing and take the values 0 and 1 only. As a consequence, stopping times are always hitting times.
openaire +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Baryon and electric charge stoppings in nuclear collisions and the role of strangeness
European Physical Journal C: Particles and FieldsIt has been challenging to quantitatively understand the stopping of incoming nucleons in nuclear collisions, and recently it has been proposed that comparing the baryon stopping with electric charge stopping can help address the question.
Mason Alexander Ross, Zi-Wei Lin
doaj +1 more source
HeliyonPurpose: To investigate the impact of smartphone viewing distance and angle on reaction times. Design: A prospective, self-controlled, single-center study. Methods: Participants engaged in a driving simulation facing a large screen with a simulated brake
Stephen A. LoBue +7 more
doaj +1 more source
Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2016 Time and the stopping distance of the electric drive with frequent starting-and-braking modes that contain embedded asynchronous motor with a recessed combined braking device depend on the moment of an electromagnet disinhibition.
V. V. Solencov, V. V. Brel
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
On Infinite Horizon Optimal Stopping of General Random Walk [PDF]
The objective of this study is to provide an alternative characterization of the optimal value function of a certain Black- Scholes-type optimal stopping problem where the underlying stochastic process is a general random walk, i.e.
Jukka Lempa
core
On complete convergence of the sum of a random number of a stable type P random elements
International Journal of Mathematics and Mathematical Sciences, 1995 Complete convergence for randomly indexed normalized sums of random elements of the form ∑j=1TnXj/ϕ(Tn) is established. The random elements {Xn} belong to a type p stable space and are assumed to be independent, but not necessarily identically ...
André Adler, Andrey Volodin
doaj +1 more source