Results 121 to 130 of about 5,285,726 (368)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Physical simulation experiment on horizontal docking well leaching for salt cavern storage

You-qi chuyun
Objective Horizontal docking well leaching is prevalently applied among salt chemical enterprises for brine extraction. However, controlling the cavern shape becomes challenging when this technique is utilized, primarily due to the absence of dissolution
Jianfu WANG, Zuoliang JIN, Jianguang LI, Jianchao JIA, Kuoyuan ZHU, Zhaoheng ZHOU   +5 more
doaj   +1 more source

New Approaches to Stress Testing the Czech Banking Sector (in English) [PDF]

This paper provides an overview of the stress testing of the Czech banking sector conducted by the Czech National Bank. The paper begins by updating historical and hypothetical stress-testing scenarios.
Jaroslav HEØMÁNEK, Martin ÈIHÁK, Michal HLAVÁÈEK   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Fault diagnosis technology overview for lithium‐ion battery energy storage station

IET Energy Systems Integration
With an increasing number of lithium‐ion battery (LIB) energy storage station being built globally, safety accidents occur frequently. Diagnosing faults accurately and quickly can effectively avoid safe accidents.
Bin Li, Peiyu Chen, Guanzheng Li, Chao Li, Kaidi Zeng, Bin Liu, Xuebin Li, Qidi Huo, Kui Jiao, Chengshan Wang   +9 more
doaj   +1 more source

Short-Term Forecasting of Czech Quarterly GDP Using Monthly Indicators [PDF]

The authors evaluate the out-of-sample forecasting performance of six competing models at horizons of up to three quarters ahead in a pseudo-real time setup. All the models use information in monthly indicators released ahead of quarterly GDP.
David Havrlant, Katerina Arnostova, Luboš Rùžièka, Peter Tóth   +3 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Switching Logic for a Direct Hybrid Electric Powertrain

Aerospace
Hybrid electric aircraft with a powertrain based on fuel cells and batteries can reduce climate-active emissions in aviation. In a direct hybrid powertrain, the fuel cell and the battery are connected in parallel, without a DC/DC converter balancing ...
Robin Fonk, Tobias Graf, Sven Paeßler, Christiane Bauer, Josef Kallo, Caroline Willich   +5 more
doaj   +1 more source

A kinetic study of furan formation during storage of shelf-stable fruit juices

, 2015
Stijn Palmers, Tara Grauwet, Miete Celus, Scheling Wibowo, Biniam Kebede, Marc Hendrickx, Ann Van Loey   +6 more
openalex   +2 more sources

The Hybrid Phillips Curve: Empirical Evidence from Transition Economies [PDF]

In this paper we estimate the hybrid New Keynesian Phillips curve for nine transition economies and examine its ability to explain inflation dynamics.
Blanka Škrabiæ, Martina Basarac, Petar Soriæ   +2 more
core