Results 121 to 130 of about 2,163,301 (317)

Switching Logic for a Direct Hybrid Electric Powertrain

Aerospace
Hybrid electric aircraft with a powertrain based on fuel cells and batteries can reduce climate-active emissions in aviation. In a direct hybrid powertrain, the fuel cell and the battery are connected in parallel, without a DC/DC converter balancing ...
Robin Fonk, Tobias Graf, Sven Paeßler, Christiane Bauer, Josef Kallo, Caroline Willich   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Physical simulation experiment on horizontal docking well leaching for salt cavern storage

You-qi chuyun
Objective Horizontal docking well leaching is prevalently applied among salt chemical enterprises for brine extraction. However, controlling the cavern shape becomes challenging when this technique is utilized, primarily due to the absence of dissolution
Jianfu WANG, Zuoliang JIN, Jianguang LI, Jianchao JIA, Kuoyuan ZHU, Zhaoheng ZHOU   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Other title: Information for storage tanks owners in Kansas

A set of 13 documents provided by the Storage Tank Section of the Kansas Department of Health and Environment with resources and information for Kansas above ground and underground storage tank owners.KANSAS STORAGE TANK PROGRAM ABOVEGROUND STORAGE TANK ...
Kansas. Department of Health and Environment. Storage Tank Section.
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Agent-Based Micro-Storage Management for the Smart Grid

, 2010
The use of energy storage devices in homes has been advocated as one of the main ways of saving energy and reducing the reliance on fossil fuels in the future Smart Grid. However, if micro-storage devices are all charged at the same time using power from
Thomas D. Voice, Ramchurn, Sarvapali D., Alex Rogers, Perukrishnen Vytelingum, Voice, Thomas D., Rogers, Alex, Ramchurn, Sarvapali D, Vytelingum, Perukrishnen, Voice, Thomas D, Nicholas R. Jennings, Jennings, Nicholas R., Jennings, Nicholas R, Sarvapali D. Ramchurn   +12 more
core  

Liver Storage

South African Medical Journal, 2018
A brief history of the development of methods of organ storage with special emphasis on liver storage is presented. The current status of experimental liver storage is reviewed, emphasizing that hypothermia is at present the principal protective factor in all successful methods of liver storage.
Spilg, Harold, Terblanche, John
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source