Results 131 to 140 of about 6,857,881 (395)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Physical simulation experiment on horizontal docking well leaching for salt cavern storage

open access: yesYou-qi chuyun
Objective Horizontal docking well leaching is prevalently applied among salt chemical enterprises for brine extraction. However, controlling the cavern shape becomes challenging when this technique is utilized, primarily due to the absence of dissolution
Jianfu WANG   +5 more
doaj   +1 more source

Modeling Comovement among Emerging Stock Markets: The Case of Budapest and Istanbul [PDF]

open access: yes
A double world index model is proposed as an ideal way of characterizing the comovement among emerging stock markets, and applied to Budapest-Istanbul as an interesting case.
Numan Ülkü
core  

The gut microbiota as an environmental factor that regulates fat storage.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2004
F. Bäckhed   +7 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Securitization of Longevity and Mortality Risk [PDF]

open access: yes
This paper deals with Alternative Risk Transfer (ART) through the securitization of longevity and mortality risks in pension plans and commercial life insurance. Various types of such mortality-linked securities are described (e.g., CATM bonds, longevity
Tomas Cipra
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

The Relation Between the Cyclically Adjusted Budget Balance and the Growth Accounting Method of Deriving Net Fiscal Effort [PDF]

open access: yes
This paper deals with the growth accounting method used to derive “net fiscal effort”. Net fiscal effort can then provide a clue about whether fiscal policy is expansionary or not, and, together with data on economic performance, can answer the question ...
Jan Zápal
core  

Phase Restructuring in Transition Metal Dichalcogenides for Highly Stable Energy Storage

open access: green, 2016
Kai Leng   +7 more
openalex   +2 more sources

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