Results 81 to 90 of about 45,481 (263)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Search for electric dipole moments in storage rings
EPJ Web of Conferences, 2016 The JEDI collaboration aims at making use of storage ring to provide the most precise measurement of the electric dipole moments of hadrons. The method makes exploits a longitudinal polarized beam. The existence an electric dipole moment would generate a
Lenisa Paolo
doaj +1 more source
A fast and lightweight tool for partially coherent beamline simulations in fourth-generation storage rings based on coherent mode decomposition. [PDF]
J Synchrotron Radiat, 2022 Sanchez Del Rio M +4 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Diagnostics of Spin-Polarized Ions at Storage Rings
AtomsPolarized heavy ions in storage rings are seen as a valuable tool for a wide range of research, from the study of spin effects in relativistic atomic collisions to the tests of the Standard Model. For forthcoming experiments, several important challenges
Anna Maiorova +3 more
doaj +1 more source
Correction of multiple nonlinear resonances in storage rings
Physical Review Special Topics. Accelerators and Beams, 2008 The correct implementation of the nonlinear lattice model is crucial to achieving the design performance in storage rings. We describe here a method for the simultaneous correction of multiple nonlinear resonances based on local resonance measurements ...
R. Bartolini +4 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Off-axis injection for storage rings with full coupling
Physical Review Accelerators and Beams, 2018 The next generation of storage ring light sources will likely operate with high linear coupling, which could potentially prevent the use of off-axis injection as large horizontal oscillation of the injected beam is coupled to the vertical plane.
Tong Zhang, Xiaobiao Huang
doaj +1 more source
AIP Conference Proceedings, 1982 The design principles for p and e+–e− storage rings are given. Space charge, tune shift, wall instability, and synchrotron radiation are among the items covered. (AIP)
openaire +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source