Results 111 to 120 of about 748,681 (316)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Smart grid interoperability use cases for extending electricity storage modeling within the IEC Common Information Model

, 2012
Copyright @ 2012 IEEEThe IEC Common Information Model (CIM) is recognized as a core standard, supporting electricity transmission system interoperability. Packages of UML classes make up its domain ontology to enable a standardised abstraction of network
Hargreaves, Nigel, Garetti Taylor, Carter, A, Taylor, Gareth, Nigel Hargreaves, Taylor, GA, Hargreaves, N, Alex Carter, Carter, Alex   +8 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Optimal Storage Rack Design for a 3D Compact AS/RS with Full Turnover-Based Storage

Compact, multi-deep (3D) automated storage and retrieval systems (AS/RS) are becoming increasingly popular for storing products with relatively low turnover on a compact area. An automated storage/retrieval crane takes care of movements in the horizontal
Yu, Y., Koster, M.B.M. de
core  

Dependable and Secure Storage in Pervasive Peer-to-Peer Systems [PDF]

, 2006
Architectural description languages (ADLs) are used within the software engineering community to support the description of high-level structure, or architecture, of software systems. A major advantage of this is the ability to analyze and evaluate trade-
Spurrett, Vicki, Ball, Rudi, de Lemos, Rogério   +2 more
core  

Data on battery health and performance: Analysing Samsung INR21700-50E cells with advanced feature engineering

Data in Brief
This dataset provides a comprehensive collection of detailed measurements from 256 Samsung INR21700-50E cells, spanning 32 batches. It uniquely combines raw data and engineered features derived from charge-discharge cycles and Hybrid Pulse Power ...
Sahar Qaadan, Aiman Alshare, Alexander Popp, Myrel Tiemann, Utz Spaeth, Benedikt Schmuelling   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A generic storage API

, 2011
Submitted to ACSC 2004 This work was supported by EPSRC grant GR/R45154 "Bulk Storage of XML Documents"We present a generic API suitable for provision of highly generic storage facilities that can be tailored to produce various individually customised ...
Dearle, Alan, Kirby, Graham, Zirintsis, Evangelos, Morrison, Ron   +3 more
core