Results 191 to 200 of about 9,435 (256)

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

open access: yesBritish Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Scalable Computation of Topological Abstractions for Scalar Data

open access: yesComputer Graphics Forum, EarlyView.
Abstract Topological data analysis has become an important tool for large scale scalar data analysis and visualization, efficiently extracting the inherent structure and features of interest of the data. However, with growing dataset sizes and complexity, it is increasingly becoming infeasible to compute topological abstractions of interest in serial ...
M. Will   +6 more
wiley   +1 more source

Improving coastal water level estimation by merging nadir-only satellite altimetry data into a hydrodynamic model. [PDF]

open access: yesEnviron Monit Assess
Bhuiyan SA   +5 more
europepmc   +1 more source

Intact coastal nursery rearing amid climate‐driven phenological shifts in threatened salmon

open access: yesConservation Biology, EarlyView.
Abstract Literature linking phenology to climate has proliferated in recent decades and shows that climate change has reorganized seasonal opportunities worldwide. However, this literature often quantifies changes in point measures of timing (e.g., beginnings and peaks) without context about duration (e.g., rearing season length) or performance (e.g ...
Stuart H. Munsch   +8 more
wiley   +1 more source

A Zeolitic Pyrimidine Framework (ZPF) Nanoplatform Co‐Delivers a DNAzyme and a Protein Prodrug for Cascade‐Activated Tumour Therapy

open access: yesCell Proliferation, EarlyView.
A zeolitic framework co‐delivers a DNAzyme and a protein prodrug to tumour cells and executes a self‐amplifying therapeutic cascade: the DNAzyme elevates tumour oxidative stress to activate a caged RNase A prodrug. This spatiotemporally controlled synergy converts a genetic input into potent enzymatic cytotoxicity, suppressing tumour growth.
Yan Huang   +4 more
wiley   +1 more source

Cultivation of Aesthetic Experience as the Aim of Environmental Art Education: A Deweyan View

open access: yesEducational Theory, EarlyView.
Abstract Challenging the dichotomy of nature and culture is broadly seen as a key aim of environmental art education. Some of the literature on the topic focuses on the question of what metaphor for the relationship between nature and culture environmental art educators should adopt and attempt to convey to their students. In this article, I argue that
Iines Leinonen
wiley   +1 more source

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