Results 1 to 2 of about 9 (2)

A novel and safe SmartCap® SC101 to develop the COVID-19 mRNA vaccine STP2104 inducing potent immune responses in humans [PDF]

Frontiers in Immunology
We have developed a 5′-capping library screening (CLS) method using over 30 different novel cap analogues. The optimal 5′-cap for the coronavirus disease 2019 (COVID-19) mRNA vaccine STP2104 was selected and applied.
Rachel Kim, Tae-Gi Uhm, Jisu Kim, Dayeon Woo, Uk-Il Kim, Xue Meng, Byounggu Yang, Suhyeon Kim, Heejene Kim, Jonghyeon Kim, Sunkyung Yoon, Joo-Young Lee, Byungkyun Kim, Dongheon Cho, Duckho Chang, Young-Hwan Cho, Kanghyun Choi, WonSeok Gwak, Hoon-Woo Lee, Jieun Bang, Elizabeth Hellström, Byoungguk Kim, Kyungjin Kim, Joo-Sung Yang   +23 more
doaj   +7 more sources

Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method [PDF]

Frontiers in Immunology
Messenger RNA (mRNA) vaccines represent a critical avenue for coronavirus disease 2019 (COVID-19) prevention. We developed a COVID-19 mRNA vaccine encoding a codon-optimized full-length ancestral spike (S) protein with a signal peptide, which employs our
Kanghyun Choi, Joo-Young Lee, Uk-Il Kim, So-Hyun Park, So-Hee Hong, Yoo-Jin Bang, Yun-Ho Hwang, Jong-Eun Lee, Suhyun Park, Soochong Kim, Sunhee Lee, Ye-Jin Yun, Tae-Gi Uhm, Inyoung Lee, Minju Kwon, EunJi Kwon, Suyeon Song, Yongkyoung Kweon, Heejene Kim, Eun-Young Oh, Jae-Yong Kim, Tae-Young Lee, Seo-Yeon Kim, Se-Eun Kim, You-Jin Kim, Seonock Lee, Ruijing Sun, Eun-Joo Lee, Gamin Kim, Hanah Lim, Byungkyun Kim, Jungho Kim, Dokeun Kim, Jae-Hwan Nam, Sang-Myeong Lee, Kyungjin Kim, Joo-Sung Yang   +36 more
doaj   +5 more sources