Results 1 to 2 of about 6 (2)

Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method. [PDF]

Front Immunol
Messenger RNA (mRNA) vaccines represent a critical avenue for coronavirus disease 2019 (COVID-19) prevention. We developed a COVID-19 mRNA vaccine encoding a codon-optimized full-length ancestral spike (S) protein with a signal peptide, which employs our
Choi K, Lee JY, Kim UI, Park SH, Hong SH, Bang YJ, Hwang YH, Lee JE, Park S, Kim S, Lee S, Yun YJ, Uhm TG, Lee I, Kwon M, Kwon E, Song S, Kweon Y, Kim H, Oh EY, Kim JY, Lee TY, Kim SY, Kim SE, Kim YJ, Lee S, Sun R, Lee EJ, Kim G, Lim H, Kim B, Kim J, Kim D, Nam JH, Lee SM, Kim K, Yang JS.   +36 more
europepmc   +4 more sources

A novel and safe SmartCap^® SC101 to develop the COVID-19 mRNA vaccine STP2104 inducing potent immune responses in humans. [PDF]

Front Immunol
We have developed a 5′-capping library screening (CLS) method using over 30 different novel cap analogues. The optimal 5′-cap for the coronavirus disease 2019 (COVID-19) mRNA vaccine STP2104 was selected and applied.
Kim R, Uhm TG, Kim J, Woo D, Kim UI, Meng X, Yang B, Kim S, Kim H, Kim J, Yoon S, Lee JY, Kim B, Cho D, Chang D, Cho YH, Choi K, Gwak W, Lee HW, Bang J, Hellström E, Kim B, Kim K, Yang JS.   +23 more
europepmc   +4 more sources