Results 211 to 220 of about 1,560,905 (327)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Accurate and Affordable Vibrational Spectra of Large Molecules: Primary, Auxiliary, and Spectator Modes in a Perturb-then-Diagonalize Framework. [PDF]

J Chem Theory Comput
Barone V, Lazzari F, Mendolicchio M.
europepmc   +1 more source

Data Sheet 1_Utility of regional STR marker variations in Tunisian and sub-Saharan populations: insights into forensic and population genetics.pdf

Asma Attaoui (21555884), Hajer Foddha (21555887), Houcemeddine Othman (798859), Hassen Ben Abdennebi (21555890), Amel Haj Khelil (21555893)   +4 more
openalex   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Patient Experiences of a Recovery-Oriented Nursing Programme in Inpatient Psychiatric Care: A Qualitative Study. [PDF]

J Psychiatr Ment Health Nurs
Öster C, Falc C, Vickman J, Lindberg MH.   +3 more
europepmc   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Soft tissue recurrence in giant cell tumor of bone: Risk factors and radiological and histopathological features. [PDF]

Acta Orthop Traumatol Turc
Mirioğlu A, Dalkır KA, Ölke HC, Kundakçı B, Bağır M, Eren K, Deveci MA.   +6 more
europepmc   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
ABSTRACT Plastic food containers used in food delivery may pose underrecognized health risks by releasing micro‐ and nanoplastics (MNPs), especially when in contact with oil‐rich foods. Here, we show that cooking oil dramatically increased MNP release from polypropylene (PP) and polyethylene (PE)‐coated containers within 3 min of microwave heating ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Serotype distribution, genotype, and antimicrobial resistance profiles of Salmonella enterica isolated from retail chicken meat in South Korea. [PDF]

Food Sci Anim Resour
Lee JB, Lim JH, Park JH, Moon HJ, Lee G, Lee CD, Kim J, Park JY, Lee KJ, Yang SJ.   +9 more
europepmc   +1 more source

Overview of European population clustering based on 23 Y-STR loci

, 2015
Serkan Doğan, Adna Ašić, Sanida Buljubašić, Larisa Bešić, Monia Avdić, Elma Feric, Mirsada Hukić, Yusuf Turan, Damir Marjanović   +8 more
openalex   +2 more sources