Results 51 to 60 of about 98,173 (339)

Genetics of strabismus

open access: yesFrontiers in Ophthalmology, 2023
Strabismus, or misalignment of the eyes, is the most common ocular disorder in the pediatric population, affecting approximately 2%–4% of children. Strabismus leads to the disruption of binocular vision, amblyopia, social and occupational discrimination,
Mayra Martinez Sanchez   +4 more
doaj   +1 more source

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation [PDF]

open access: yes, 2006
The planar cell polarity (PCP) pathway is conserved throughout evolution, but it mediates distinct developmental processes. In Drosophila, members of the PCP pathway localize in a polarized fashion to specify the cellular polarity within the plane of the
Brinkman, Brendan C.   +9 more
core   +1 more source

Medical expenditure for strabismus: a hospital-based retrospective survey

open access: yesCost Effectiveness and Resource Allocation, 2022
Background and aims The misconception of the purpose of strabismus treatment has, on the one hand, affected the motivation of strabismus patients to seek care and, on the other hand, has resulted in strabismus not being covered by health insurance, both ...
Lei Yang   +5 more
doaj   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco   +18 more
wiley   +1 more source

An Influence of Birth Weight, Gestational Age, and Apgar Score on Pattern Visual Evoked Potentials in Children with History of Prematurity

open access: yesNeural Plasticity, 2015
Purpose. The objective of our study was to examine a possible influence of gestational age, birth weight, and Apgar score on amplitudes and latencies of P100 wave in preterm born school-age children. Materials and Methods. We examined the following group
Marta Michalczuk   +4 more
doaj   +1 more source

Congenital cataracts presenting as a childhood squint

open access: yesBritish and Irish Orthoptic Journal, 2012
Aim:  A timely reminder that a small posterior subcapsular cataract could present with a squint. Methods:  A case series is reported of 4 patients who were referred to the paediatric ophthalmology service for management of a squint.
Shanel Sharma   +2 more
doaj   +1 more source

Amblyopia [PDF]

open access: yes, 2016
Amblyopia is, aside from refractive error, the most common cause of visual loss in children. Thus amblyopia is a serious public health issue. When diagnosed and treated early, the visual losses may be easily reversed.
Levi, DM
core  

Strabismus Recognition Using Eye-Tracking Data and Convolutional Neural Networks

open access: yesJournal of Healthcare Engineering, 2018
Strabismus is one of the most common vision diseases that would cause amblyopia and even permanent vision loss. Timely diagnosis is crucial for well treating strabismus.
Zenghai Chen, Hong Fu, W. Lo, Z. Chi
semanticscholar   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

open access: yesAdvanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang   +16 more
wiley   +1 more source

A commonly occurring genetic variant within the NPLOC4–TSPAN10–PDE6G gene cluster is associated with the risk of strabismus

open access: yesHuman Genetics, 2019
Strabismus refers to an abnormal alignment of the eyes leading to the loss of central binocular vision. Concomitant strabismus occurs when the angle of deviation is constant in all positions of gaze and often manifests in early childhood when it is ...
D. Plotnikov   +8 more
semanticscholar   +1 more source

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