Results 111 to 120 of about 638,045 (294)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Design of sprocket tooth profile for composite pitch block chain transmission
Jixie chuandongObjectiveThe composite pitch block chain drive is widely used in the cold drawing machine and other similar equipment in the mechanical industry. The block chain has a special structure with different pitches between internal and external links, which is
LU Jianfu +5 more
doaj
Polymorphic Aβ42 fibrils adopt similar secondary structure but differ in cross-strand side chain stacking interactions within the same β-sheet. [PDF]
, 2020 Formation of polymorphic amyloid fibrils is a common feature in neurodegenerative diseases involving protein aggregation. In Alzheimer's disease, different fibril structures may be associated with different clinical sub-types.
Duo, Lan +5 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecules, 2018 Fatty acids play a major role in determining membrane biophysical properties. Staphylococcus aureus produces branched-chain fatty acids (BCFAs) and straight-chain saturated fatty acids (SCSFAs), and can directly incorporate exogenous SCSFAs and straight ...
Kiran B. Tiwari +2 more
doaj +1 more source
Cartesian path control of a two-degree-of-freedom robot manipulator [PDF]
The problem of cartesian trajectory control of a closed-kinematic chain mechanism robot manipulator with possible space station applications is considered.
Nguyen, Charles C., Pooran, Farhad J.
core +1 more source
Low-energy electron scattering from C_4H_9OH isomers [PDF]
, 2010 We present differential, integral, and momentum-transfer cross sections for elastic scattering of low-energy electrons by three butanol isomers, isobutanol, t-butanol, and 2-butanol.
Bettega, M. H. F. +2 more
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
High efficient shape coding based on the representation of contour and chain code
Tongxin xuebao, 2014 A high efficient lossless shape coding scheme was proposed based on the representation of contour and chain code. The object contours are firstly extracted and thinned to be single-pixel width.
Zhong-jie ZHU, Yu-e WANG, Gang-yi JIANG
doaj +2 more sources