Results 151 to 160 of about 5,505,744 (329)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Static Stiffness Analysis of a New Scissor-type Telescoping and Lifting Mechanism

Jixie chuandong, 2018
Combining hart straight-line mechanism with scissors mechanism,a new type of deployable model in straight-line motion which consists of revolute joint only is proposed.
Hao Gang, Chang Boyan, Li Wenqi
doaj  

Inter-Unit Consistency and Validity of 10-Hz GNSS Units in Straight-Line Sprint Running. [PDF]

Sensors (Basel), 2022
Chahal AK, Lim JZ, Pan JW, Kong PW.
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Differences in equine spinal kinematics between straight line and circle in trot. [PDF]

Sci Rep, 2021
Byström A, Hardeman AM, Serra Bragança FM, Roepstorff L, Swagemakers JH, van Weeren PR, Egenvall A.   +6 more
europepmc   +1 more source

Machine Learning for Real-Time Prediction of Damaging Straight-Line Convective Wind

, 2017
Ryan Lagerquist, A. McGovern, Travis M. Smith   +2 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Kinematic Analysis During Straight Line Free Swimming in Horses: Part 2 - Hindlimbs. [PDF]

Front Vet Sci, 2021
Santosuosso E, Leguillette R, Vinardell T, Filho S, Massie S, McCrae P, Johnson S, Rolian C, David F.   +8 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Spectral Transition for Dirac Operators with Electrostatic δ -Shell Potentials Supported on the Straight Line. [PDF]

Integr Equ Oper Theory, 2022
Behrndt J, Holzmann M, Tušek M.
europepmc   +1 more source