Results 131 to 140 of about 6,718,270 (416)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Conceptual Design and Parametric Optimization of a New Multileveled Horsetail Structure for Bicycle Helmets

open access: yesAdvanced Engineering Materials, EarlyView., 2023
This study aims to explore the feasibility of using a structure inspired by the features of horsetail and human spine as the potential helmet liner, targeting at mitigation of acceleration‐induced injuries. A parametric study is conducted to investigate the effect of individual geometrical variables in the design, indicating its capability to reduce ...
Bing Leng   +3 more
wiley   +1 more source

Ultrasound Vascular Elastography as a Tool for Assessing Atherosclerotic Plaques – A Systematic Literature Review

open access: yesUltrasound International Open, 2016
Atherosclerosis is a widespread disease that accounts for nearly 3-quarters of deaths due to cardiovascular disease. Ultrasound elastography might be able to reliably identify characteristics associated with vulnerable plaques.
B. Mahmood   +3 more
doaj   +1 more source

The Strained State Cosmology [PDF]

open access: yesProceedings of Frontiers of Fundamental Physics 14 — PoS(FFP14), 2011
Starting from some relevant facts concerning the behavior of the universe over large scale and time span, the analogy between the geometric approach of General Relativity and the classical description of an elastic strained material continuum is discussed.
openaire   +11 more sources

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

open access: yesMolecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Flexural Behavior of Bidirectionally Graded Lattice

open access: yesAdvanced Engineering Materials, EarlyView., 2023
An experimental study of the bending behavior of bidirectional body‐centered cubic lattice beams is conducted in comparison to uniform and unidirectional counterparts of electron beam melted SS 316 L. Experimental results are used to develop and validate a finite element model which is subsequently used to conduct parametric studies to assess the ...
Chamini Rodrigo   +4 more
wiley   +1 more source

Prediction of Debye-Scherrer diffraction patterns in arbitrarily strained samples [PDF]

open access: yes, 2013
The prediction of Debye-Scherrer diffraction patterns from strained samples is typically conducted in the small strain limit. Although valid for small deviations from the hydrostat (such as the conditions of finite strength typically observed in diamond anvil cells) this assertion is likely to fail for the large strain anisotropies (often of order 10 ...
arxiv   +1 more source

The confinement of concrete in compression using CFRP composites – effective design equations

open access: yesJournal of Civil Engineering and Management, 2014
This paper presents the results of an experimental study on the behaviour of axially loaded short concrete columns, with different cross sections that have been externally strengthened with carbon fibre-reinforced polymer (CFRP) sheets.
Riad Benzaid, Habib-Abdelhak Mesbah
doaj   +1 more source

Graphene Textile Strain Sensor with Negative Resistance Variation for Human Motion Detection.

open access: yesACS Nano, 2018
Recently, wearable devices have been attracting significantly increased interest in human motion detection and human physiological signal monitoring. Currently, it is still a great challenge to fabricate strain sensors with high performance and good fit ...
Zhen Yang   +8 more
semanticscholar   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

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