Results 61 to 70 of about 329,998 (301)

Cyclic responses and microstructure sensitivity of Cr-based turbine steel under different strain ratios in low cycle fatigue regime

Materials & Design, 2021
When turbine steel services, i.e., startup and shutdown processes, the cyclic mechanical stress caused by the asymmetry loading conditions is introduced.
Xiufang Gong, Tianjian Wang, Qingsong Li, Yongjie Liu, Hong Zhang, Wei Zhang, Quanyi Wang, Qingyuan Wang   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Multiscale Investigation of Strain Energy Density for Fatigue Life Prediction

, 2017
A fatigue life prediction method using strain energy density as a prediction parameter has had success predicting the lifetimes greater than 105 cycles for room and elevated temperatures under axial, bending, and shear loading for different material ...
M.-H. H. Shen, Casey M. Holycross, Tommy J. George, Onome E. Scott-Emuakpor   +3 more
core   +1 more source

Strain acting on adsorption of C60 onto graphene from DFTB algorithm

Carbon Trends, 2021
Density functional tight-binding calculations have been employed to study the interaction between C60 with pristine and strained single layer graphene, respectively.
Li Jing, Zhao Dandan, Zhang Lin
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Study on the influence of elastic modulus heterogeneity on in-situ stress and its damage to gas shale reservoirs

Journal of Natural Gas Geoscience, 2018
Shale heterogeneity has a significant effect on drilling and completions, hydraulic fracturing, as well as hydrocarbon development performance. However, it lacks representation of rock damage/failure caused by the mechanical heterogeneity and “stress ...
Daobing Wang, Hongkui Ge, Bo Yu, Dongsheng Wen, Jun Zhou, Dongxu Han, Lu Liu   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Experimental and numerical study of the evolution of stored and dissipated energies in a medium carbon steel under cyclic loading [PDF]

, 2013
Lien vers la version éditeur: http://www.sciencedirect.com/science/article/pii/S0167663613000288To obtain robust estimations of the fatigue limit from energy-based fatigue criteria, constitutive laws must include a correct description of the energy ...
MOREL, Franck, CUILLERIER, Daniel, MAREAU, Charles   +2 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source