Results 81 to 90 of about 3,092,566 (289)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Characterization of Indentation-Induced Pattern Using Full-Field Strain Measurement

, 2011
[[abstract]]In this study DIC-based strain analysis software was successfully developed and its strain resolution lies on the order of 2.3×10-4-3.1×10-4.
Shih, Ming-Hsiang, 童士恒, Lu, Yan-Yu, Kuo, Jui-Chao   +3 more
core  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Early resistance rehabilitation improves functional regeneration following segmental bone defect injury

npj Regenerative Medicine
Many studies have explored different loading and rehabilitation strategies, yet rehabilitation intensity and its impact on the local strain environment and bone healing have largely not been investigated.
Kylie E. Williams, Julia Andraca Harrer, Steven A. LaBelle, Kelly Leguineche, Jarred Kaiser, Salil Karipott, Angela Lin, Alyssa Vongphachanh, Travis Fulton, J. Walker Rosenthal, Farhan Muhib, Keat Ghee Ong, Jeffrey A. Weiss, Nick J. Willett, Robert E. Guldberg   +14 more
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Fiber Optic Sensor of Axial Strain and Dynamic Transverse Force Based on Intensity Demodulation

Sensors
This paper presents a fiber-optic sensor with intensity demodulation for simultaneous measurement of dynamic transverse force and axial strain. The sensor uses a Sagnac loop filter with a polarization-maintaining photonic crystal fiber (PM-PCF) that is ...
Cezary Kaczmarek, Malgorzata Detka
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Fibre segment interferometry using code-division multiplexed optical signal processing for strain sensing applications [PDF]

, 2013
A novel optical signal processing scheme for multiplexing fibre segment interferometers is proposed. The continuous-wave, homodyne technique combines code-division multiplexing with single-sideband modulation.
Charrett, Thomas O. H., Tatam, Ralph P., Kissinger, Thomas   +2 more
core   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source