Results 51 to 60 of about 366,004 (267)

Shear strain localization in elastodynamic rupture simulations

Geophysical Research Letters, 2008
We study strain localization as an enhanced velocity weakening mechanism on earthquake faults. Fault friction is modeled using Shear Transformation Zone (STZ) Theory, a microscopic physical model for non‐affine rearrangements in granular fault gouge. STZ
Eric G. Daub, M. Lisa Manning, Jean M. Carlson   +2 more
doaj   +1 more source

Strain Localization during Equal-Channel Angular Pressing Analyzed by Finite Element Simulations

Metals, 2018
Equal-Channel Angular Pressing (ECAP) is a method used to introduce severe plastic deformation into a metallic billet without changing its geometry.
Tobias Daniel Horn, Christian Bert Silbermann, Philipp Frint, Martin Franz-Xaver Wagner, Jörn Ihlemann   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mechanical and material heterogeneity, strain localization and deformation rate effects in crushable expanded polystyrene foams

Frontiers in Mechanical Engineering
Low-density expanded polystyrene (EPS) foams are widely used in lightweight energy absorption systems such as helmets due to their ability to readily mold into complex geometries.
Francis Yao, Meet Joshi, Megan Bland-Rothgeb, Peter Cripton, Duane Cronin, John Magliaro   +5 more
doaj   +1 more source

Comparing In Situ DIC Results from an Etched Surface with a Gold Speckled Surface

Metals, 2019
A ferrite-pearlite two-phase steel was investigated using in situ scanning electron microscope (SEM) tensile testing combined with digital image correlation (DIC). Two different speckled patterns were used and compared.
Christian Oen Paulsen, Egil Fagerholt, Tore Børvik, Ida Westermann   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Review of Theoretical, Experimental and Numerical Advances on Strain Localization in Geotechnical Materials

Applied Sciences
Strain localization is a critical phenomenon in geotechnical materials, serving as a precursor to the failure of engineering structures such as slopes, foundations, and tunnels. This paper presents a comprehensive review of the theoretical, experimental,
Yonghui Li, Anyuan Sun, Feng Zhu
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Syn-Emplacement Fracturing in the Sandfell Laccolith, Eastern Iceland—Implications for Rhyolite Intrusion Growth and Volcanic Hazards

Frontiers in Earth Science, 2018
Felsic magma commonly pools within shallow mushroom-shaped magmatic intrusions, so-called laccoliths or cryptodomes, which can cause both explosive eruptions and collapse of the volcanic edifice.
Tobias Mattsson, Steffi Burchardt, Steffi Burchardt, Bjarne S. G. Almqvist, Erika Ronchin, Erika Ronchin   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source