Results 71 to 80 of about 377,276 (310)

Deformation Localization and Damage Constitutive Model of Raw Coal and Briquette Coal under Uniaxial Compression

Geofluids, 2022
In order to compare and analyze the difference in deformation and damage law of soft and hard porous media materials, the digital image correlation is used to evaluate the heterogeneous development of strain fields of hard and brittle raw coal material ...
Lina Ge, Fu Yi, Changbo Du, Junxia Zhou, Zhenglong Cui, Tao Wang   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Small quantity but large effect — How minor phases control strain localization in upper mantle shear zones

, 2015
Low viscosity domains such as localized shear zones exert an important control on the geodynamics of the uppermost mantle. Grain size reduction and subsequent strain localization related to a switch from dislocation to diffusion creep is one mechanism to
Herwegh, Marco, Müntener, Othmar, Linckens, Jolien   +2 more
core   +1 more source

Strain localization in ductile rocks: A comparison of natural and simulated pinch and-swell structures [PDF]

, 2016
We study pinch-and-swell structures in order to uncover the onset of strain localization and the change of deformation mechanisms in layered ductile rocks.
Peters, Max, Herwegh, Marco, Regenauer-Lieb, Klaus, Berger, Alfons   +3 more
core   +1 more source

Polymer-like double necking deformation in an FeCoCrV medium entropy alloy

Materials Research Letters
Necking in metallic materials is a crucial strain localization phenomenon traditionally regarded as the termination of uniform deformation and the sign of impending fracture.
Si Gao, Yao Xiao, Jiankun Liu, Reza Gholizadeh, Myeong-Heom Park, Shuhei Yoshida, Wenqi Mao, Yanzhong Tian, Nobuhiro Tsuji   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Prediction of strain localization in sheet metal forming using elastoplastic-damage model and localization criterion

, 2007
The aim of this work is to study the strain localization during the plastic deformation of sheets metals. This phenomenon is precursor for the fracture of drawing parts, thus its prediction using advanced behavior models is important in order to obtain ...
BALAN, Tudor, ABED-MERAIM, Farid, HADDAG, Badis   +2 more
core  

Prediction of the initial thickness of shear band localization based on a reduced strain gradient theory

, 2011
Plastic flow localization in ductile materials subjected to pure shear loading and uniaxial tension is investigated respectively in this paper using a reduced strain gradient theory, which consists of the couple-stress (CS) strain gradient theory ...
冯彪, Chen, SH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China, 陈少华, 王自强, 魏悦广   +4 more
core   +1 more source