Results 91 to 100 of about 4,685,644 (340)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Localization in inelastic rate dependent shearing deformations

, 2016
Metals deformed at high strain rates can exhibit failure through formation of shear bands, a phenomenon often attributed to Hadamard instability and localization of the strain into an emerging coherent structure.
Katsaounis, Theodoros, Lee, Min-Gi, Tzavaras, Athanasios   +2 more
core   +1 more source

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix [PDF]

, 2015
Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and diseased tissues--particularly in development, wound healing, tissue regeneration and cancer--the mechanisms that direct the assembly and regulate hierarchical ...
Gourdon, Delphine, Klotzsch, Enrico, Kubow, Kristopher E., Luna, Sheila, Smith, Michael L., Vogel, Viola, Vukmirovic, Radmila, Zhe, Lin   +7 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Strain localization and anisotropic correlations in a mesoscopic model of amorphous plasticity [PDF]

, 2012
A mesoscopic model for shear plasticity of amorphous materials in two dimensions is introduced, and studied through numerical simulations in order to elucidate the macroscopic (large scale) mechanical behavior.
Argon, Baret, Ben-Zion, Berveiller, Bocquet, Bulatov, Bulatov, Bulatov, Chen, Dahmen, Damien Vandembroucq, Delogu, Demkowicz, Demkowicz, Demkowicz, Ernsberger, Eshelby, Falk, Goldenberg, Homer, Jagla, Kardar, Kardar, Lemaître, Lemaître, Leonforte, Leonforte, Leonforte, Leonforte, Lerner, Lerner, Lewandowski, Lund, MacNeill, Maloney, Maloney, Maloney, Maloney, Maloney, Marsh, Mehdi Talamali, Narayan, Packard, Peter, Picard, Rodney, Rodney, Rottler, Rottler, Rountree, Schuh, Shi, Shi, Shi, Sollich, Stéphane Roux, Takeshi, Talamali, Talamali, Talati, Tanguy, Taylor, Tsamados, Tsamados, Vandembroucq, Vandembroucq, Varnik, Varnik, Viljo Petäjä, Zaiser, Zaoui, Zhang   +71 more
core   +5 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Strain localization as a key to reconciling experimentally derived flow-law data with dynamic models of continental collision [PDF]

, 2018
. : Published strength profiles predict strength discontinuities within and/or at the base of continental crust during compression. We use finite element models to investigate the effect of strength discontinuities on continental collision dynamics.
Ellis, Susan, Pfiffner, Adrian, Wissing, Silke   +2 more
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Surface flaws control strain localization in the deformation of Cu$\vert$Au nanolaminates

, 2019
We carried out matched experiments and molecular dynamics simulations of the compression of nanopillars prepared from Cu$\vert$Au nanolaminates with 25 nm layer thickness.
Gola, Adrien, Pastewka, Lars, Schwaiger, Ruth, Zhang, Guang-Ping   +3 more
core   +1 more source