Results 91 to 100 of about 377,276 (310)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Failure analysis based on microvoid growth for sheet metal during uniaxial and biaxial tensile tests [PDF]

, 2013
The aim of the presented investigations is to perform an analysis of fracture and instability during simple and complex load testing by addressing the influence of ductile damage evolution in necking processes.
Abbassi, Fethi, Mistou, Sébastien, Zghal, Ali   +2 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Strain gradient effect on initiation of adiabatic shear localization in metal matrix composites

, 2000
In this paper, the strain gradient effect on the initiation of adiabatic shear localization in particle reinforced metal matrix composites (MMCp) is investigated.
Ling Z(凌中), Bai YL(白以龙), Dai, LH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100080, Peoples R China., Dai LH(戴兰宏)   +3 more
core  

Preliminary Results on Mechanical Degradation and Strain Evolution of Carrara Marble Under Freeze–Thaw Cycles and Acid Weathering

Geotechnics
Environmental stressors, such as freeze–thaw (F–T) cycling and acid rain, affect the durability of carbonate rocks used in engineering and cultural heritage structures.
Azemeraw Wubalem, Chiara Caselle, Anna Maria Ferrero, Gessica Umili   +3 more
doaj   +1 more source

Prediction of strain localization in nonlinear strain paths

, 2021
The simulation of nonlinear strain paths is important both for the design and development of tools for sheet metal forming processes, which can present very complex geometries, as well as for the prediction of failures during the process. Despite the evolution of computational methods, the prediction of ductile failure continues to be a challenge ...
openaire   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Corrigendum: Syn-Emplacement Fracturing in the Sandfell Laccolith, Eastern Iceland—Implications for Rhyolite Intrusion Growth and Volcanic Hazards

Frontiers in Earth Science, 2020
Tobias Mattsson, Steffi Burchardt, Steffi Burchardt, Bjarne S. G. Almqvist, Erika Ronchin, Erika Ronchin   +5 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source