Results 111 to 120 of about 4,685,644 (340)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Flow transitions in two-dimensional foams

, 2006
For sufficiently slow rates of strain, flowing foam can exhibit inhomogeneous flows. The nature of these flows is an area of active study in both two-dimensional model foams and three dimensional foam. Recent work in three-dimensional foam has identified
C. Macosko, Christopher Gilbreth, Michael Dennin, R. B. Bird, R. B. Bird, Scott Sullivan   +5 more
core   +1 more source

Strain localization and fatigue crack formation at (0001) twist boundaries in titanium alloys

, 2021
S. Hémery, J. Stinville, Fulin Wang, M. Charpagne, M. G. Emigh, T. Pollock, V. Valle   +6 more
semanticscholar   +1 more source

Strain localization and crack formation effects on stress-strain response of ductile iron

, 2017
The strain localization and crack formation in ferritic-pearlitic ductile iron under tension was investigated by in-situ tensile tests.
Keivan Amiri Kasvayee, E. Ghassemali, K. Salomonsson, S. Sujakhu, S. Castagne, A. Jarfors   +5 more
semanticscholar   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Preliminary Results on Mechanical Degradation and Strain Evolution of Carrara Marble Under Freeze–Thaw Cycles and Acid Weathering

Geotechnics
Environmental stressors, such as freeze–thaw (F–T) cycling and acid rain, affect the durability of carbonate rocks used in engineering and cultural heritage structures.
Azemeraw Wubalem, Chiara Caselle, Anna Maria Ferrero, Gessica Umili   +3 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Corrigendum: Syn-Emplacement Fracturing in the Sandfell Laccolith, Eastern Iceland—Implications for Rhyolite Intrusion Growth and Volcanic Hazards

Frontiers in Earth Science, 2020
Tobias Mattsson, Steffi Burchardt, Steffi Burchardt, Bjarne S. G. Almqvist, Erika Ronchin, Erika Ronchin   +5 more
doaj   +1 more source