Results 71 to 80 of about 7,742,171 (287)

Speckle‐Tracking Echocardiography in Dogs With Patent Ductus Arteriosus: Effect of Percutaneous Closure on Cardiac Mechanics

open access: yesJournal of Veterinary Internal Medicine, 2016
Background Patent ductus arteriosus (PDA) is 1 of the most common congenital heart defects in dogs and percutaneous closure is effective in achieving ductal closure; PDA closure is associated with abrupt hemodynamic changes.
I. Spalla   +4 more
doaj   +1 more source

Strain hardening behaviors and strain rate sensitivity of gradient-grained Fe under compression over a wide range of strain rates

open access: yes, 2016
In the present work, gradient-grained Fe was synthesized by means of surface mechanical grinding treatment, and then the compression behaviors of the coarse-grained Fe and the gradient-grained Fe were investigated under both quasi-static and dynamic ...
Chen P   +5 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

STRAIN RATE EFFECT ON THE FAILURE STRAIN AND HARDNESS OF METALLIC ARMOR PLATES SUBJECTED TO HIGH VELOCITY PROJECTILE IMPACT [PDF]

open access: yesJournal of Engineering Science and Technology, 2006
Post impact strain measurements of damaged plates were carried out experimentally after launching a spherical steel projectile at varying velocities against a fixed thin plate targets made of copper and steel materials and constrained at their outer ...
QASIM H. SHAH
doaj  

Strain rate sensitivity of sintered silver nanoparticles using rate-jump indentation

open access: yes, 2018
Nanoindentation experiments were performed at room temperature on pressure-less sintered silver nanoparticles (AgNP) samples. Two representative die attach solder materials: sintered electrically conductive silver adhesive and conventional Sn-3.0Ag ...
冯义辉   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

What do we currently know from in vivo bone strain measurements in humans? [PDF]

open access: yes, 2011
Bone strains are the most important factors for osteogenic adaptive responses. During the past decades, scientists have been trying to describe the relationship between bone strain and bone osteogenic responses quantitatively. However, only a few studies
Rittweger, Jörn   +2 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

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