Results 61 to 70 of about 2,812,703 (301)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Strain-Rate and Stress-Rate Models of Nonlinear Viscoelastic Materials

Mathematics
The paper is devoted to the modeling of nonlinear viscoelastic materials. The constitutive equations are considered in differential form via relations between strain, stress, and their derivatives in the Lagrangian description.
Claudio Giorgi, Angelo Morro
doaj   +1 more source

Use of strain, strain rate, tissue velocity imaging, and endothelial function for early detection of cardiovascular involvement in patients with beta-thalassemia

Annals of Pediatric Cardiology, 2017
Background: Global ventricular function often remains normal in patients with beta-thalassemia major. (β-TM) until late. Tissue Doppler and strain imaging may be useful to assess regional myocardial function abnormalities in these patients.
Abhinav Gupta, Aditya Kapoor, Shubha Phadke, Archana Sinha, Shridhar Kashyap, Roopali Khanna, Sudeep Kumar, Naveen Garg, Satyendra Tewari, Pravin Goel   +9 more
doaj   +1 more source

Perga under compressive loading [PDF]

Journal on Processing and Energy in Agriculture, 2017
Paper dealt with the experimental testing of the perga cylinder samples at the compressive loading in the longitudinal direction. The perga is bee product and it represents the material created from the bee pollen by means of the lactic fermetation ...
Kubík Ľubomír, Brindza Ján, Brovarskyi Valeryi, Velychko Serhii   +3 more
doaj   +1 more source

Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering [PDF]

, 2013
Background: The production of bioethanol from lignocellulose hydrolysates requires a robust, D-xylose-fermenting and inhibitor-tolerant microorganism as catalyst.
Boles, Eckhard, Bonini, Beatriz M., Demeke, Mekonnen M., Den Abt, Tom, Deprez, Sylvie, Dietz, Heiko, Dumortier, Francoise, Foulquie-Moreno, Maria R., Li, Yingying, Lidén, Gunnar,, Lund University., Mutturi, Sarma,, Thevelein, Johan M., Verplaetse, Alex   +13 more
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Evaluation of left ventricular performance in hypertensive patients by speckle tracking echocardiography: Correlation with brain natriuretic peptide

The Egyptian Heart Journal, 2014
Background: Hypertension results in hemodynamic changes ranging from maladaptive left ventricular hypertrophy (LVH) to heart failure. Two-dimensional speckle tracking echocardiography (2D-STE) allows rapid and accurate analysis of regional and global ...
Waleed Abdou Ibrahim Hamed, Abdallah Mostafa Kamal, Mohammed Fahmy Noamany, Mahmoud Aly Soliman, Mai Mohammed Abdel Ra’ouf   +4 more
doaj   +1 more source

Properties of the strain rate sensitivity function produced by the linear viscoelasticity theory and existence of its maximum with respect to strain and strain rate

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2020
Strain rate sensitivity of stress-strain curves family generated by the Boltzmann–Volterra linear viscoelasticity constitutive equation (with an arbitrary relaxation modulus) under uni-axial loadings at constant strain rates is studied analytically as ...
Andrew Vladimirovich Khokhlov
doaj   +1 more source

Retention of ductility in high-strength steels [PDF]

, 1969
To produce high strength alloy steel with retention of ductility, include tempering, cooling and subsequent tempering. Five parameters for optimum results are pretempering temperature, amount of strain, strain rate, temperature during strain, and ...
Parker, E. R., Zackay, V. F.
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source