Results 101 to 110 of about 4,528,270 (350)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Wireless Passive LC Temperature and Strain Dual-Parameter Sensor

Micromachines, 2020
There is an increasing demand for bearing temperature and strain monitoring in high-speed rotating systems. This study proposes a new multiresonance, multiplexing, wireless, passive inductance capacitance (LC) temperature and strain sensor.
Ya Wang, Qiulin Tan, Lei Zhang, Baimao Lin, Meipu Li, Zhihong Fan   +5 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

High Precision, Small Size and Flexible FBG Strain Sensor for Slope Model Monitoring

Sensors, 2019
In this paper, a soft fiber Bragg grating (FBG) strain sensor was constructed of a rubber strip, FBGs and steel plates, which exhibits the advantages of high precision and a small size.
Hongbin Xu, Xinyu Zheng, Weigang Zhao, Xu Sun, Feng Li, Yanliang Du, Bo Liu, Yang Gao   +7 more
doaj   +1 more source

Azobenzene-based gel coated fibre Bragg grating sensor for moisture measurement [PDF]

, 2016
A fibre Bragg grating sensor is coated with a novel polymer gel in order to investigate its suitability for nondestructive measurement of moisture in materials that can potentially lose their integrity due to moisture ingress.
Moniruzzaman, Mohammed, Rock, John
core   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Wearable Flexible Strain Sensor Based on Three-Dimensional Wavy Laser-Induced Graphene and Silicone Rubber

Sensors, 2020
Laser-induced graphene (LIG) has the advantages of one-step fabrication, prominent mechanical performance, as well as high conductivity; it acts as the ideal material to fabricate flexible strain sensors.
Lixiong Huang, Han Wang, Peixuan Wu, Weimin Huang, Wei Gao, Feiyu Fang, Nian Cai, Rouxi Chen, Ziming Zhu   +8 more
doaj   +1 more source

Low power wireless sensor network for structural health monitoring of buildings using MEMS strain sensors and accelerometers [PDF]

, 2012
Within the MEMSCON project, a wireless sensor network was developed for structural health monitoring of buildings to assess earthquake damage. The sensor modules use custom-developed capacitive MEMS strain and 3D acceleration sensors and a low power ...
Bertsch, Nicolas, Brebels, Steven, Saillen, Nicolas, Santana-Corte, Juan, Sterken, Tom, Torfs, Tom, Trapani, Davide, Van den Hoven, Richard, Zonta, Daniele   +8 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source