Results 81 to 90 of about 2,300,817 (293)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Light harvesting self-powered strain sensor using 3C-SiC/Si heterostructure

, 2022
Herein we report a light harvesting self-powered strain sensor using a monolithic heterojunction structure. Firstly, a strain sensor in a geometry of a cantilever with a 3C-SiC/Si heterojunction sensing element is fabricated.
Nguyen, NT, Nguyen, Nam-Trung, Van Nguyen, D, Nguyen, H, Dao, DV, Tong, Braiden, Dinh, Toan, Tong, B, Takahashi, H, Nguyen, Hung, Nguyen, Thanh, Tran, CD, Nguyen, T, Dinh, T, Dao, Dzung Viet, Tran, Canh-Dung, Nguyen, Duy Van, Dau, VT, Dau, Van Thanh, Takahashi, Hidetoshi   +19 more
core   +1 more source

Wearable Flexible Strain Sensor Based on Three-Dimensional Wavy Laser-Induced Graphene and Silicone Rubber

Sensors, 2020
Laser-induced graphene (LIG) has the advantages of one-step fabrication, prominent mechanical performance, as well as high conductivity; it acts as the ideal material to fabricate flexible strain sensors.
Lixiong Huang, Han Wang, Peixuan Wu, Weimin Huang, Wei Gao, Feiyu Fang, Nian Cai, Rouxi Chen, Ziming Zhu   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Pressure-Insensitive Self-Attachable Flexible Strain Sensor with Bioinspired Adhesive and Active CNT Layers [PDF]

, 2020
Flexible tactile sensors are required to maintain conformal contact with target objects and to differentiate different tactile stimuli such as strain and pressure to achieve high sensing performance. However, many existing tactile sensors do not have the
Joosung Lee, Hwang, Insol, Jeong, Hoon Eui, Minho Seong, Lee, Joosung, Insol Hwang, Seong, Minho, Hoon Eui Jeong   +7 more
core   +1 more source

Nonlinear Strain Engineering via Meta‐Material Substrates for Flexible Sensors With Simultaneously Enhanced Sensitivity and Wide Sensing Range

Global Challenges
Flexible strain sensors face an unresolved trade‐off between sensitivity and sensing range. We present a meta‐material‐based sensor platform (meta‐sensor) that overcomes this by engineering local strain input to the sensing element.
Gyeongyeol Lee, Sung‐Wook Kim, Yong Whan Choi   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Ultrasensitive strain sensor enhanced by Bonded Light Emitting Diodes

, 2021
Herein we report a strain sensor with SiC/Si heterostructure exhibiting performance enhanced toward ultra-sensitivity using a bonded pico-light-emitting-diode.
Nguyen, NT, Nguyen, Nam-Trung, Abu Riduan Md Foisal, Foisal, Abu Riduan Md, Nguyen, H, Hung Nguyen, Dinh, Toan, Pham, Tuan Anh, Nguyen, Hung, Nguyen, Thanh, Phan, HP, Nguyen, T, Tuan-Khoa Nguyen, Md Foisal, AR, Tran Canh-Dung, Hoang-Phuong Phan, Phan, Hoang-Phuong, Dau, VT, Dau, Van Thanh, Toan Dinh, Vu, H, Pham, TA, Canh-Dung Tran, Dao, DV, Nam-Trung Nguyen, Nguyen, Tuan-Khoa, Tran, CD, Nguyen, TK, Van Thanh Dau, Thanh Nguyen, Dinh, T, Dao, Dzung Viet, Dzung Viet Dao, Tuan Anh Pham, Hieu Vu, Vu, Hieu   +35 more
core   +1 more source

High Precision, Small Size and Flexible FBG Strain Sensor for Slope Model Monitoring

Sensors, 2019
In this paper, a soft fiber Bragg grating (FBG) strain sensor was constructed of a rubber strip, FBGs and steel plates, which exhibits the advantages of high precision and a small size.
Hongbin Xu, Xinyu Zheng, Weigang Zhao, Xu Sun, Feng Li, Yanliang Du, Bo Liu, Yang Gao   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source