Results 51 to 60 of about 2,300,817 (293)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Temperature and strain discrimination using a single tilted fibre Bragg grating [PDF]

, 2007
A fibre optic sensor capable of discriminating between temperature and strain, using a single fibre Bragg grating, is presented. The technique exploits the core–cladding mode coupling of a tilted fibre Bragg grating (TFBG). The core and cladding modes
Tatam, Ralph P., Chehura, Edmon, James, Stephen W.   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Ultrahigh Resolution Multiplexed Fiber Bragg Grating Sensor for Crustal Strain Monitoring

IEEE Photonics Journal, 2012
We demonstrated a multiplexed fiber Bragg grating (FBG) sensor with static strain resolution of 10 nanostrain (nε) for crustal strain monitoring. Each sensor unit consists of a pair of identical FBGs for strain sensing and reference, respectively.
Q. Liu, T. Tokunaga, K. Mogi, H. Matsui, H. F. Wang, T. Kato, Z. He   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Piezo-Resistive Properties of Bio-Based Sensor Yarn Made with Sisal Fibre

Sensors, 2021
In this work, a sensor yarn based on a natural sisal yarn containing a non-electro-conductive core impregnated with PVA polymer and coated by PEDOT:PSS polymer as an electro-conductive sheath was investigated.
Ahmed Abed, Zineb Samouh, Cédric Cochrane, Francois Boussu, Omar Cherkaoui, Reddad El Moznine, Julien Vieillard   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Investigation of the Transient Behavior of a Cantilever Beam Using PVDF Sensors

Sensors, 2012
In this paper, a PVDF film sensor was used to measure the transient responses of a cantilever beam subjected to an impact loading. The measurement capability of a PVDF sensor is affected by the area of the PVDF film sensor and the signal conditioner ...
Shan-Ying Pan, Yu-Hsi Huang, Chien-Ching Ma   +2 more
doaj   +1 more source

Liquid Metal‐Based Strain Sensor with Ultralow Detection Limit for Human–Machine Interface Applications

Advanced Intelligent Systems, 2021
Flexible strain sensors play vital role in human–machine interaction. Despite their vast development, a strain sensor having broad strain sensing range, ultralow detection limit, and negligible hysteresis still remains a challenge. Herein, a liquid metal
Yuanzhao Wu, Youlin Zhou, Waqas Asghar, Yiwei Liu, Fali Li, Dandan Sun, Chao Hu, Zhenguang Wu, Jie Shang, Zhe Yu, Run-Wei Li, Huali Yang   +11 more
doaj   +1 more source