Results 31 to 40 of about 1,347,908 (268)

T2* Magnetic Resonance Imaging Uncovers Hemosiderin Burden in Pediatric Hemophilia: A Call for Sensitive Imaging Biomarkers

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia   +6 more
wiley   +1 more source

Rediscovery of Saprolegniales in the Philippines Reveals New Phylogenetic and Ecological Insights

open access: yesMycobiology
Saprolegniales (Phylum Oomycota), a group of fungus-like oomycetes, include economically important opportunistic pathogens responsible for disease outbreaks in aquatic organisms, yet their occurrence in tropical regions remains poorly documented. In this
Annrhe H. Siscar, Reuel M. Bennett
doaj   +1 more source

The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson’s Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells

open access: yesCells, 2021
Parkinson’s disease (PD) and multiple system atrophy (MSA) are caused by two distinct strains of disease-associated α-synuclein (αSynD). Recently, we have shown that olfactory mucosa (OM) samples of patients with PD and MSA can seed the aggregation of ...
Chiara Maria Giulia De Luca   +11 more
doaj   +1 more source

Mapping Childhood Cancer Care Services in Oceania: Methodological Lessons From the SIOP Global Mapping Programme

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT The International Paediatric Oncology Society Global Mapping Programme aims to collect data on global paediatric oncology services by continent, with Africa and Latin America completed. This study reports on the methodology and lessons learned for Oceania, a unique continent with resource disparity across countries, multiple small island ...
Trisha Soosay Raj   +16 more
wiley   +1 more source

Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae

open access: yesVeterinary Research, 2021
To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting several captive, free ranging and wild cervid species. Responsible for marked population declines in North America, its geographical spread is now becoming a ...
Katayoun Moazami-Goudarzi   +3 more
doaj   +1 more source

Impact of Japan's 2024 Physician Work‐Style Reform on Pediatric Hematology–Oncology: Educational Implications in a 2‐Year Survey

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Japan's 2024 physician work‐style reform introduced legally binding limits on physicians’ working hours, but its impact on education and workforce sustainability in pediatric hematology–oncology (PHO) remains unclear. Procedure We conducted a repeated cross‐sectional study with structured quantitative items and free‐text responses ...
Kiyohiko Kaizu   +7 more
wiley   +1 more source

Shape Sensing for an UAV Composite Half-Wing: Numerical Comparison between Modal Method and Ko’s Displacement Theory

open access: yesAerospace, 2022
Shape sensing is the reconstruction of the displacement field of a structure from some discrete surface strain measurements and is a key technology for structural health monitoring. The aim of this paper is to compare two approaches to shape sensing that
Filippo Valoriani   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Numerical Study of the Effect of Elastomer and Cement of Stress Absorbers on the Reduction of Stresses in Tibia and Tibial Bone Analysed by Finite Element Method

open access: yesNano Biomedicine and Engineering, 2018
Metal alloys have been the materials of choice since the start of orthopaedic surgery. Orthopedic materials must fulfill the mechanical, biological and physical necessities of their proposed utilization. Knee joint is the most complex joint in human body,
Abdelkader Mestar   +3 more
doaj   +1 more source

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