Results 61 to 70 of about 699,160 (266)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A meta‐analysis of the hamstring tendon strands reconstruction in ACL: Functional outcomes based on strands number

Journal of Experimental Orthopaedics
Purpose Comparing the effectiveness and safety of four‐, five‐, six‐ and eight‐strand hamstring tendon graft topologies for anterior cruciate ligament (ACL) restoration was the aim of this meta‐analysis. In order to provide evidence‐based recommendations
Juan M. Fernández‐Domínguez, José L. Martín‐Alguacil, Marta Esteban‐Blanco, Manuel Vides‐Fernández, Joan Carles Monllau   +4 more
doaj   +1 more source

From LLMs to sustainable proteins: fine-tuning and prompt engineering for multi-agent AI in waste carbon-utilising microbial protein production

Carbon Capture Science & Technology
The global demand for sustainable protein sources has accelerated the need for intelligent tools that can rapidly process and synthesise domain-specific scientific knowledge.
Alexander D. Kalian, Jaewook Lee, Stefan P. Johannesson, Lennart Otte, Christer Hogstrand, Miao Guo   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Usage of Textile Material Properties while Laying them on a Convex Surface

Механика машин, механизмов и материалов, 2013
The method of laying a smooth woven textiles and multiaxial fabrics on a convex surfaces is proposed. An example of a square tissue T-13 sample placement on a spherical surface is considered.
Yu.V. Vasilevich , V.M. Sakhonenko , S.V. Sakhonenko , K.A. Gorely , E.V. Malyutin   +4 more
doaj  

Talking with a Ghost: Semi-Virtual Coupled Levitated Oscillators

Photonics
Mesoscopic particles levitated by optical, electrical or magnetic fields act as mechanical oscillators with a range of surprising properties, such as tuneable oscillation frequencies, access to rotational motion, and remarkable quality factors.
Ronghao Yin, Yugang Ren, Deok Young Seo, Anoushka Sinha, Jonathan D. Pritchett, Qiongyuan Wu, James Millen   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Optimized machine learning enabled intrusion detection 2 system for internet of medical things

Franklin Open
This research paper proposes an intrusion detection system that combines particle swarm optimization and AdaBoost algorithms to classify and detect malware-related records in innovative health app platforms.
Zhenyang Sun, Gangyi An, Yixuan Yang, Yasong Liu   +3 more
doaj   +1 more source