Results 91 to 100 of about 812,407 (248)

Potential effect of human chorionic gonadotropin‐induced extracellular vesicle RNAs on mouse ovarian granulosa cells

FEBS Open Bio, EarlyView.
To mimic the LH action in the ovary, granulosa‐cell and mouse models were stimulated by hCG, which changed RNA profiles within extracellular vesicles (EVs), and potentially hCG‐responsive EV RNAs increased the number of recipient ovarian cells. EV‐associated RNAs are potential intermediaries of hCG signaling.
Natchanok Puangjit, Nobuhiko Takahashi, Yuki Maruyama, Shota Mayama, Katsueki Ogiwara, Chika Fujimori, Atsushi P. Kimura   +6 more
wiley   +1 more source

Programmable energy landscapes for kinetic control of DNA strand displacement.

, 2016
DNA is used to construct synthetic systems that sense, actuate, move and compute. The operation of many dynamic DNA devices depends on toehold-mediated strand displacement, by which one DNA strand displaces another from a duplex.

core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

mtSSB in vivo occupancy reflects strand-displacement mtDNA replication.

, 2014
(A) Occupancy of mtSSB and TFAM analyzed by strand-specific qPCR amplification of ChIP samples. (B) Strand-specific ChIP-seq profile of mtSSB binding to mtDNA. The origins of replication are indicated.
Javier Miralles Fusté (669465), Örjan Persson (669468), Nasim Sabouri (669469), Sjoerd Wanrooij (669466), Xuefeng Zhu (261768), Elisabeth Jemt (669467), Maria Falkenberg (30090), Yonghong Shi (363283), Claes M. Gustafsson (261769)   +8 more
core   +1 more source

Molecular Diagnosis in Children With Febrile Seizures: Beyond the Conventional Clinical Classification

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Febrile seizures (FS) are currently classified as simple or complex primarily to describe seizure characteristics, with limited ability to identify the underlying etiology. We evaluated whether molecular diagnosis could complement conventional classification and improve the diagnosis and management of FS.
Jia Wang, Mengna Zhang, Yangyang Wang, Xiuyu Shi, Baoguang Li, Xiuxia Wang, Dan Sun, Sanqing Xu, Jianbo Zhao, Lijun Du, Qiming Pang, Xiaoming Liu, Chunhui Tang, Xiaohua Li, Jiuwei Li, Yanli Ma, Jianxiang Liao, Gulixian Abudureyimu, Jianmin Liang, Yuan Wang, De Wu, Jian Wu, Liping Zou   +22 more
wiley   +1 more source

Strong sequence-dependence in RNA/DNA hybrid strand displacement kinetics [PDF]

Strand displacement reactions underlie dynamic nucleic acid nanotechnology. The kinetic and thermodynamic features of DNA-based displacement reactions are well understood and well predicted by current computational models. By contrast, understanding of
Ouldridge, Thomas E., Jurinovic, Krizan, Goetz, John, Ouldridge, Thomas, Smith, Francesca G., Smith, Francesca, Stevens, molly, Goertz, John P., Stevens, Molly M.   +8 more
core   +1 more source

RNA pathogen detection with one-step reverse transcription PCR and strand-displacement based signal amplification [PDF]

, 2013
A novel detection method for RNA pathogens based on one-step reverse transcription PCR is introduced here. This method utilized the reverse transcriptase activity and the 5'-nuclease activity of TaqM1 DNA polymerase to transform target RNA into cDNA. The
Chen, Haodong, Huang, Xin, Tang, Z (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Peoples R China, Marx, Andreas, Streckenbach, Frank, Tang, Zhuo, Du, Feng   +6 more
core   +1 more source

Gyroid Structured Globugraphite Carbon Foam With Hierarchical and Tailored Pore Size

Advanced Engineering Materials, EarlyView.
Secondary sacrificial templates were designed and printed to create a defined network within a porous carbon. Lattices thermally degrades during the sintering process. Lattices are imprinted into the ceramic template and transferred to the morphology of Globugraphite.
Christiane Roller, Justin Neumann, David Ploch, Lennard M. Flohr, Julian Karsten, Fabian A. Riebesehl, Bodo Fiedler   +6 more
wiley   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Achieving High ON State Current through Ferroelectric Polarization‐Dependent Interfacial Resistance Switching in Undoped Orthorhombic HfO2 Films

Advanced Functional Materials, EarlyView.
Ferroelectric tunnel junction devices based on epitaxial undoped ferroelectric HfO2 films demonstrate stable switching endurance of over 106 switching cycles, low write voltages of ±3 V, 16 measured resistance states, and neuromorphic capability.
Markus Hellenbrand, Nuno Estrócio, Ji S. Kim, Babak Bakhit, Marian C. Istrate, Corneliu Ghica, Tiago Rebelo, Nives Strkalj, Abin Varghese, Bernardo Almeida, Luís S. Marques, Bipin Rajendran, Judith L. MacManus‐Driscoll, José P. B. Silva   +13 more
wiley   +1 more source