Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Attitudes towards abortion and contraception in rural and urban Burkina Faso [PDF]
Using results from the ethnographic literature and two qualitative studies on people’s representations of different means of birth control (abstinence, contraception, abortion) in two populations in Burkina Faso (one rural and one urban), we designed a ...
Clémentine Rossier
core
Diaspora, Développement et Citoyenneté: Les Migrants Originaires du Bassin du Fleuve Sénégal [PDF]
, 2005 The author analyses the contribution of the diaspora on the development of their ...
Olivier le Masson, Samba Yatera
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The silent burden of anaemia in Tanzania children:a community-based study [PDF]
, 2003 Objective was to document the prevalence, age-distribution, and risk factors for anaemia in Tanzanian children less than 5 years old,thereby assisting in the development of effective strategies for controlling anaemia.\ud \ud Cluster sampling was used to
Armstrong Schellenberg, J R M +6 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Les NTIC dans les PME : Stratégies, capacités organisationnelles et avantages concurrentiels [PDF]
Les résultats de recherche dont on rend compte ici s'intéressent aux conditions de création d'avantages concurrentiels en terme de coûts, de qualité et de nouveaux produits ou services à partir des usages de NTIC dans les PME.
Martine Gadille, Serge Amabile
core
Determinants of DMC technologies adoption among smallholders in the Lake Alaotra area, Madagascar : Document de travail BV lac n° 45 [PDF]
, 2008 Les techniques de systèmes de semis direct sur couverture végétale (SCV) sont diffusées depuis une dizaine d'années à Madagascar. Ils répondent à des objectifs de préservation de l'environnement, de création de revenus et de réduction de la pauvreté, en ...
Andriamalala, Herizo +5 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A New FRamework to Study Decision in Organisation [PDF]
The purpose of this communication is to display an original decision model - the Decisional Fit Model. Based on other models of fit, this model focuses on decision making when using a decision support system.
Cécile Godé-Sanchez +1 more
core