Results 51 to 60 of about 3,906,096 (300)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Numerical simulation and measurement analysis of the temperature field of artificial freezing shaft sinking in Cretaceous strata

AIP Advances, 2019
Targeting the challenging analysis of the temperature field of the artificial freezing shaft sinking projects in Cretaceous strata, this study used the Hongqinghe air shaft freezing project as an example to perform a numerical simulation and measurement ...
Zhishu Yao, Haibing Cai, Weipei Xue, Xiaojian Wang, Zongjin Wang   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Gas migration for terrestrial gas hydrates in the Juhugeng mining area of Muli basin, Qilian Mountains, Northwest China

Energy Exploration & Exploitation, 2020
The Juhugeng mining area in the Qilian Mountains is the only district of China where terrestrial gas hydrate has been found. This paper aimed at studying the gas migration for gas hydrates based on fluid inclusion and apatite fission track experiments ...
Anmin Wang, Jing Li, Yingchun Wei, Chengwei Yang, Jing Nie, Daiyong Cao   +5 more
doaj   +1 more source

Thoughts on roadway and chamber construction technology in deep rock for mineral–geothermal co-mining

工程科学学报, 2022
With the depletion of shallow mineral resources, China’s mineral mining is gradually developing into deep rock mining, which will become an important source of mineral resources in China.
Xiang-sheng CHEN, Xian-long WU, Xiao-hua BAO, Hong-zhi CUI, Chao-yang SONG, Zhi-qiang LIU   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Research on the Temperature Field and Frost Heaving Law of Massive Freezing Engineering in Coastal Strata

Advances in Materials Science and Engineering, 2021
In this study, based on the background of massive freezing engineering in coastal strata, the thermal physical parameters and some freezing laws of soil were obtained through soil thermal physical tests and frozen soil frost heaving tests. When the freezing temperatures were −5°C, −10°C, −15°C, and −20°C, the frost heaving rates of the soil were 0.53%,
Chaochao Zhang, Dongwei Li, Junhao Chen, Guanren Chen, Chang Yuan, Zecheng Wang, Guosheng Ding, Xin Chen, Minghai Xia, Shengfu Wang, Bo Zhang, Ru He, Xin Yi   +12 more
openaire   +2 more sources

Structural plasticity of climbing fibers and the growth-associated protein GAP-43 [PDF]

, 2013
Structural plasticity occurs physiologically or after brain damage to adapt or re-establish proper synaptic connections. This capacity depends on several intrinsic and extrinsic determinants that differ between neuron types.
Giorgio Grasselli, Piergiorgio Strata, Grasselli G., Strata P., Giorgio eGrasselli, Piergiorgio eStrata   +5 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Evolutionary strata on the X chromosomes of the dioecious plant Silene latifolia: Evidence from new sex-linked genes [PDF]

, 2007
Despite its recent evolutionary origin, the sex chromosome system of the plant Silene latifolia shows signs of progressive suppression of recombination having created evolutionary strata of different X-Y divergence on sex chromosomes. However, even after
Bergero, Roberta, Forrest, Alan, Kamau, Esther, Charlesworth, Deborah   +3 more
core   +1 more source