Results 61 to 70 of about 468,976 (219)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Strategic Selection of Telecom Operators to Counter OTT
Dianxin kexue, 2014 The influence which OTT brings to carriers was analyzed，the differences between OTT and telecom operators were compared，and the strategic selection for the domestic telecom operators was proposed by domestic and foreign telecom operators case study.
Min Zhang, Jie Song, Xiaofeng Liu
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Ankara Avrupa Çalışmaları Dergisi, 2017 Erasmus+ Avrupa Birliği’nin eğitim, öğretim, gençlik ve spor alanı hibe programıdır. Program 2014-2020 yılları arasında uygulanacaktır. 28 Avrupa Birliği üyesi ülke ve diğer 5 ülke olmak üzere toplam 33 Program Ülkesinin katılımına açıktır. Bu ülkelerden
Vesife Hatısaru
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
SCIENTIFIC/THEORETIC APPROACHES TO INNOVATIVE MANAGEMENT (WITH TRANSPORT AS AN EXAMPLE)
Модернизация, инновация, развитие, 2016 Innovative management is a type of interactive activities based on a system of direct and reverse links with innovative process, the object of the management.
O. N. Dounayev
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
MHR. Providing a New Perspective in HR in terms of Crisis Management
International Journal of Business Science and Applied Management, 2018 Crises have become an integral part of everyday life. They affect humans, their communities, and their organizations. The tragedies, natural catastrophes, and other crises that occur worldwide threaten the public's welfare, people's mental and physical ...
Nizamidou, C., Vouzas, F.
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