Results 81 to 90 of about 468,976 (219)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

From neglect to necessity: a community case study on the strategic recovery of 57 ventilators during the COVID-19 pandemic

Frontiers in Health Services
BackgroundThe COVID-19 pandemic precipitated a critical global shortage of mechanical ventilators, life-saving devices essential for managing patients with severe respiratory complications.
Meshari Rashed Albuqami, Ghadah Sulaiman Alsaleh, Ghadah Sulaiman Alsaleh, Ibrahim Saud Altrair, Marie Hamed Alqahtani, Fahad Mansour Alanazi, Mohmmed Fahad Alqahtani, Faisal Hawas Alattawi, Abdulaziz Abdullah Alshehri, Abdulrahman Bakhat Alzahrani, Abdulrahman Ayed Alruwaili, Reem Abdulrahman Alshehri, Ali Mohmmed Alshehri, Sarah Hassan Alqahtani   +13 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

VARIABLES VINCULADAS CON LA PLANEACIÓN DE RECURSOS HUMANOS A NIVEL TERRITORIAL / VARIABLES TO CONSIDER ON THE PLANNING OF THE HUMAN RESOURCES AT THE TERRITORIAL LEVEL

Revista Científica de Ingeniería Industrial, 2013
El presente artículo tiene como objetivo la utilización de la vía experimental para la identificación del grupo de variables y sus interrelaciones e influencias sobre la planeación de recursos humanos en el nivel territorial.
Rodobaldo Martínez-Vivar, Clara Elena Marrero-Fornaris, Reyner Pérez-Campdesuñer   +2 more
doaj  

Interactive model of the China-US-Russia triangle relationship: Theoretical analysis and development prospect

RUDN Journal of Public Administration
This study examines the interactions within the China-US-Russia triangle using the two types of strategic triangle theory. By analyzing Dittmer’s four models - family triangle, romantic triangle, stable marriage, and unit veto - it explores the evolving ...
Nikolay N. Yagodka, Ying Wang
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Operational and real-time Business Intelligence [PDF]

Informatică economică, 2008
A key component of a company’s IT framework is a business intelligence (BI) system. BI enables business users to report on, analyze and optimize business operations to reduce costs and increase revenues.
Daniela Ioana SANDU
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source