Results 111 to 120 of about 26,820,360 (304)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Strategic Analysis of Participants in the Provision of Elderly Care Services-An Evolutionary Game Perspective. [PDF]
Int J Environ Res Public Health, 2021 He J, Luo X, Zhang Z, Yu Y.
europepmc +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Цифровая трансформация, 2018 The article deals with the specifics of the application of information technologies in the transport sphere. The importance of improving the safety of the vehicle operation is substantiated, and possible ways of solving this issue are presented.
N. S. Jankevich
doaj +2 more sources
Digital Diplomacy: The Impact of Technology on Modern Diplomacy and Foreign Policy. Current Realities and Future Prospects [PDF]
Romanian Journal of European AffairsThe paper examines how digital technologies are changing the field of diplomacy. It looks at how diplomacy has evolved from traditional practices to a modern form where technology is essential. The paper covers various digital tools, such as social media,
Carola Frey
doaj
Strategic analysis of intimate partner violence (IPV) and cycle of violence in the autobiographical text -When I Hit You. [PDF]
Heliyon, 2022 Sangeetha J +3 more
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Цифровая трансформация, 2018 Features of small innovative entrepreneurship as the intellectual intermediary between a science and manufacture are considered. Trends in the development of small innovative entrepreneurship in the Republic of Belarus, as well as trends in the ...
A. A. Kosenko
doaj +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source