Results 131 to 140 of about 29,308,301 (338)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Sustainable Development and Engineering EconomicsThe article discusses the problem of digitalization of oil and gas field design, the purpose of which is to develop a strategic map for managing the process of digital transformation at the stage of field design.
Marina Malashenko +2 more
doaj +1 more source
Conversação entre Abordagens da Estratégia em Organizações: Escolha Estratégica, Cognição e Instituição [PDF]
RAC: Revista de Administração Contemporânea, 2010 This paper was written with the objective of checking on the treatment given to the concept of organizational strategy within each of the strategic choice, cognitive and institutional approaches.
Valéria S. da Fonseca +1 more
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Crisis management:A STRATEGIC APPROACH [PDF]
مطالعات مدیریت بهبود و تحول, 1997 Survival of the firm, faced with crisis is considered to be of strategic concern for its st akh o lde rs , As such mature act.io ns taken to help organizations, avert crises or more effectively manage those that do occure, is of ...
nader mazlumi
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Strategic management decision making is among the most complex functions in entrepreneurship, especially, in context of improvement of competitiveness level of enterprises.
Fedotova, Kristīne +2 more
core
The effects of organizational politics and strategic posture on innovation performance
, 2009 Strategic posture is crucial to family-owned businesses for survival. In this study, we investigate the effects of organizational politics and strategic posture (as measured by the Miles-Snow strategic typology of prospectors, analyzers, defenders, and
Özgener, Şevki +3 more
core
The Use of Strategic Planning Tools and Techniques by Hotels in Jordan [PDF]
Purpose: This paper aims to understand the use of strategic planning tools and techniques and the nature of its relationship with managers’ views of the strategic planning process in hotels.
Al Khattab, Adel +2 more
core +3 more sources