Results 31 to 40 of about 29,088 (261)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Strategic Competence and L2 Speaking Assessment

Working Papers in Applied Linguistics and TESOL, 2015
Assessing second language speaking has long been an important part of language testing in both large-scale assessment settings and in smaller scale classroom-based assessments.
Yuna Seong
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Profile of Strategic Competence Education for Sustainable Development Based on Gender in Nature Schools

Quagga
To advance sustainable development, competencies cannot be taught, but students must develop through experience and reflection to acquire action. One of the important competencies to be applied in education is strategic competence.
Dina Mardiana, Suhendar, Aa Juhanda, Ridwansyah   +3 more
doaj   +1 more source

The Effectiveness of Teaching Mechanics Using Practical Experiments in Developing Strategic Competence and Design Thinking for STEM School Students [PDF]

مجلة تربويات الرياضيات
The research aimed to identify the effectiveness of teaching the mechanics curriculum using practical experiments in developing strategic competence and design thinking among STEM school students.
Reda Mossad Elsaid, Rehan Ibrahim Elserry   +1 more
doaj   +1 more source

A "critical period" in the use of language learning strategies [PDF]

Zbornik Radova Filozofskog Fakulteta u Prištini, 2017
Age of students is one of the factors that may significantly influence the use of language learning strategies. The aim of this paper is to determine whether there is a "critical period" when primary school learners tend to change their use of strategies
Pilipović Vesna B., Glušac Tatjana Lj.
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Role of Digital Capabilities in Achieving Strategic Efficiency: A survey study in the traffic directorate of the independent Zakho administration according to the perspective of its leaders

تنمیة الرافدین
This study aimed to explore the correlation and impact of digital capabilities on strategic competence within the Traffic Directorate of the Independent Zakho Administration in the Kurdistan Region of Iraq.
Dlofan Ameen Salman, Jagar Mustafa Ismail   +1 more
doaj   +1 more source

Communicative Competence and Oral Language Usage of Filipino Learners in English

International Journal of Educational Management and Development Studies, 2023
Communicative competence is heavily emphasized under the K-12 Basic Education Curriculum as language is the primary instrument of thought. Hence, the goal of this study is to create speaking activities to reinforce communicative competence and oral ...
Rosel Bernadette A. Bautista, Jasper M. Del Valle   +1 more
doaj   +1 more source