Results 51 to 60 of about 1,221,883 (313)

MANAGEMENT, BUDGETING AND COST-BENEFIT ANALYSIS: OPERATIONAL AND STRATEGIC ASPECT

Статистика и экономика, 2016
The article describes the problems of management of costs, results and assets of an organization in conditions of economic instability. The analysis of new and innovative systems for obtaining information about the costs, the use of new types of cost ...
Pavel P. Kholodov, Galina I. Zyablitskaya   +1 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Features of strategic management of enterprises in conditions of war

Innovation and Sustainability, 2023
Domestic enterprises in modern times operate in a rather turbulent environment, influenced by war, pandemics, and logistical changes. All of this presents new challenges for enterprise management, requiring a higher level of strategic vision, continuous ...
I. Yepifanova, V. Dzhedzhula, R. Kaplun
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Factors Affecting the Use of Cost Management Systems in Iran Petrochemical Industry [PDF]

مدیریت بهره وری, 2010
In today’s world, the existence of many of the industries depends on their ability to increase the accuracy of the cost management system, which accounts for the reduction of expenses, or in more general terms, the end cost of items, as an important ...
Asgar Pakmaram, Bijan Mohammadi, Jafar Beikzad   +2 more
doaj  

Improving the organizational and economic mechanism of strategic management accounting of enterprises' costs in the context of the clustering of the economy in Ukraine

Економіка, управління та адміністрування, 2020
There are modern economic conditions in which Ukrainian cluster function makes it necessary to adapt to the consequences of the pandemic, which led to a decline in the economy around the world.
P.V. Hlasov
doaj   +1 more source

The concept of strategic cost management: a strategic aspect [PDF]

, 2015
У статті проаналізовано існуючі концепції управління витратами, зроблений акцент на їх основних положеннях. Досліджено теоретичне і практичне значення концепції стратегічного управління витратами (Strategic Cost Management).
Єршова, Наталя Юріївна
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