Results 101 to 110 of about 6,693,188 (270)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

The decision paradoxes motivating Prospect Theory : The prevalence of the paradoxes increases with numerical ability

open access: yes, 2019
Prospect Theory (PT: Kahneman & Tversky, 1979) of risky decision making is based on psychological phenomena (paradoxes) that motivate assumptions about how people react to gains and losses, and how they weight outcomes with probabilities.
Nilsson, Håkan   +2 more
core   +2 more sources

AI-driven Decision-Making Models for Strategic Management: A Comprehensive Framework for Organizational Excellence in the Digital Era

open access: yesJISR on Computing
– The rapid development of artificial intelligence (AI) technologies has fundamentally transformed strategic decision-making processes in organizations worldwide. Traditional strategic management frameworks are increasingly being augmented or replaced by
Syed Ali Raza Naqvi   +3 more
doaj   +1 more source

Can fuzzy Multi-Criteria Decision Making improve Strategic planning by balanced scorecard? [PDF]

open access: yes, 2016
Strategic management is momentous for organizational success and competitive advantage in an increasingly turbulent business environment. Balanced scorecard (BSC) is a framework for evaluating strategic management performance which translates strategy ...
Talaei-Khoei, Amir Talaei-Khoei   +5 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

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