Results 91 to 100 of about 1,832,046 (296)

Strategic Design Fiction

open access: yesAkademisk Kvarter, 2018
This article aims to discuss the role of the dominant critical tradition of design fiction, as well as defending the merits of a pragmatic and strategic view on design fiction, as potentially real solutions.
Thessa Jensen, Peter Vistisen
doaj   +1 more source

Strategic Approaches to the Development and Management of Personal Tutorial Systems in UK Higher Education [PDF]

open access: yes, 2006
This chapter explores our experience, over nine years, of taking a strategic approach to personal tutoring within University of the Arts London. University of the Arts London comprises (at time of writing) five colleges and is specialist within the ...
Blythman, Margo   +4 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Actualizing sustainable transport: the interplay between public policy instruments and shared mobility providers’ business models

open access: yesEuropean Transport Research Review
Cities around the world are trying to understand if and how to regulate urban mobility in a way that stimulates innovation and supports business while also promoting public values and accelerating a sustainability transition.
Erika Kriukelyte   +2 more
doaj   +1 more source

SUSTAINABLE PRODUCT SERVICE SYSTEMS DESIGN: TOOLS FOR STRATEGICS ANALYSIS

open access: yesMix Sustentável, 2017
The present paper discusses the tools for phase of Strategic Analysis for the process of Sustainable Product-Service System Design. It explores the cumulative experience obtained at the Design & Sustainability Research Center of UFPR, on case studies ...
Aguinaldo dos Santos, Naotake Fukushima
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Preparing design students for strategic design

open access: yesFORMakademisk, 2012
This paper deals with how the visual approach from a design process can help inform companies about future opportunities at a strategic level. The paper follows an innovation project where design students worked with five companies at a 1-day workshop ...
Jørgen Rasmussen   +2 more
doaj   +1 more source

Information Design for Strategic Coordination of Autonomous Devices with Non-Aligned Utilities

open access: yes, 2017
In this paper, we investigate the coordination of autonomous devices with non-aligned utility functions. Both encoder and decoder are considered as players, that choose the encoding and the decoding in order to maximize their long-run utility functions ...
Tomala, Tristan, Treust, Maël Le
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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