Results 81 to 90 of about 1,832,046 (296)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A multi-agent based system to enable strategic and operational design coordination [PDF]

, 2000
This paper presents two systems which individually focus on different aspects of design coordination, namely strategic and operational. The systems were developed in parallel and individually contain related models that represent specific frames from a ...
Coates, Graham, Duffy, Alex H. B., Hills, Bill, Whitfield, Robert Ian   +3 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Strategic Design of Mobile Agents.

AI Mag., 2002
Much of the economic value of electronic commerce comes from the automation of interactions between businesses and individuals. Game theory is a useful set of tools that can be used by designers of electronic-commerce applications in analyzing and engineering of automated agents and communication protocols.
openaire   +2 more sources

Designing experiences strategically

Journal of Business Research, 2014
Companies willing to enter into the experience economy have available procedures for experience design and evaluation but not for strategic decision-making on what experiences to incorporate into their offering. This study presents a procedure for identifying experiences and for assessing their customer value.
Alcantara Alcover, Enrique, Martínez Guillamón, Natividad, Artacho Ramírez, Miguel Ángel, Zamora Alvarez, Tomas Augusto   +3 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Designing social behaviour change in households: sustainable mobility intervention and follow-up study

Frontiers in Sustainability
Limiting global warming to 1.5 degrees requires consistent action by people to change their lifestyles in order to limit annual household-related carbon emissions to 2.5 tonnes per person by 2030.
Saga Sofia Santala, Saga Sofia Santala, Merja Honkanen, Michael Lettenmeier, Michael Lettenmeier, Michael Lettenmeier, Jari Kolehmainen, Salla Lahtinen   +7 more
doaj   +1 more source

Choosing a Company's Building Design: Models for Strategic Design Decisions [PDF]

Improving the linkage between real estate strategy and building design can help competitive business strategy. Differentiating building design from product design is important. Problems in making design choices derive from received paradigmatic knowledge
M. Gordon Brown
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source