Results 151 to 160 of about 12,314,950 (299)

Multi-Stimuli-Responsive Hydrogels: From Strategic Design to Biomedical Applications. [PDF]

Gels
Yi S, Li HY, Chang R.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The strategic role of Design in the organisation: cultivating employee engagement

Many non-design organisations are interested in integrating design culture into their operations. Strategic Design's role is to craft, activate, and nurture Design interventions into corporate culture, starting from single employees. Designers could feed
Melazzini
core  

Cost-effectiveness and alternatives to the B-1 strategic bomber / Ron Huisken.

, 1979
Includes bibliographical references.On 30 June 1977, President Carter announced that the United States would not proceed with production and deployment of the B-l strategic bomber.
Huisken, Ronald Herman
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Strategic design of precautionary measures for airport passengers in times of global health crisis Covid 19: Parametric modelling and processing algorithms. [PDF]

J Air Transp Manag, 2020
Dabachine Y, Taheri H, Biniz M, Bouikhalene B, Balouki A.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Superhydrophobic Wearable Strain Sensors: From Strategic Design to Robustness Paradigm. [PDF]

Nanomicro Lett
Song H, Liang Y, Zhang G, Long K, Shi K, Han X, Liu C, Qing Y.   +7 more
europepmc   +1 more source

Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold. [PDF]

RSC Adv, 2020
Yimchuen W, Kadonosono T, Ota Y, Sato S, Kitazawa M, Shiozawa T, Kuchimaru T, Taki M, Ito Y, Nakamura H, Kizaka-Kondoh S.   +10 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Participatory Strategic Foresight Framework: Embracing Future Thinking in Design Education and Community Vision Planning

Changes in society, student expectations, and technology continue to shift the ways in which we learn. The contemporary state of design education is being affected by changes in the professional realm that requires a future thinking-centered design to ...
Khamis, Noha E.
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