Results 101 to 110 of about 122,273 (299)

Diagnostic Procedure for Inter-Sector Relationships in the Model of Municipal Development

Agrisost, 2017
Several methods were applied to design a new diagnostic procedure of inter-sector relationships, and the coordination between development strategies and key economic sectors within the strategic planning system in the municipality of Nuevitas, province ...
Concepción O de la Torre Rodríguez, Ramón González Fontes, Santos Pineda Zamora, José Luis Céspedes Cansino   +3 more
doaj  

Progress towards implementation of ACT malaria case-management in public health facilities in the Republic of Sudan: a cluster-sample survey

BMC Public Health, 2012
Background Effective malaria case-management based on artemisinin-based combination therapy (ACT) and parasitological diagnosis is a major pillar within the 2007-2012 National Malaria Strategic Plan in the Sudan.
Abdelgader Tarig M, Ibrahim Abdalla M, Elmardi Khalid A, Githinji Sophie, Zurovac Dejan, Snow Robert W, Noor Abdisalan M   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Perspectives On Blood-Based Point-Of-Care Diagnostics

Open Access Emergency Medicine, 2019
Karalee Quig,1 Elizabeth G Wheatley,2 Matthew O’Hara2 1POC Testing Consultant, Aurora, CO, USA; 2Boston Strategic Partners, Inc., Boston, MA, USACorrespondence: Matthew O’HaraBoston Strategic Partners, Inc., 4 Wellington Street Suite 3 ...
Quig K, Wheatley EG, O’Hara M
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Diagnostics of enterprise bankruptcy occurrence probability in an anti-crisis management: modern approaches and classification of models

Vìsnik Žitomirsʹkogo Deržavnogo Tehnologìčnogo Unìversitetu: Ekonomìčnì Nauki, 2015
Diagnostics of enterprise bankruptcy occurrence probability is defined as an important tool ensuring the viability of an organization under conditions of unpredictable dynamic environment.
I.V. Zhalinska
doaj  

CARDIAC STENTING IN DEXTROCARDIA- AN APPROACH TO A RARE HEART ANOMALY: A CASE-BASED REVIEW

Anti-Aging Eastern Europe
Dextrocardia with situs inversus, often called mirror dextrocardia, is an uncommon congenital heart defect where the heart’s apex points to the right side. The success of percutaneous coronary intervention (PCI) may contribute to its impact on individual
Darkhan Suigenbayev, Issabek Kerimkulov, Akerke Auanassova, Zhanibek Orazaly, Galiya Assanova   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source