Results 101 to 110 of about 1,672,360 (286)

Stokes diagnostics of simulated solar magneto-convection [PDF]

, 2007
We present results of synthetic spectro-polarimetric diagnostics of radiative MHD simulations of solar surface convection with magnetic fields. Stokes profiles of Zeeman-sensitive lines of neutral iron in the visible and infrared spectral ranges emerging
Shelyag, S., S. K. Solanki, Vögler, Alexander, Solanki, S., Schüssler, M., M. Schüssler, Shelyag, Sergiy, Solanki, Sami K., Schüssler, Manfred, A. Vögler, Vögler, A., S. Shelyag   +11 more
core   +1 more source

Strength, weakness, opportunities and challenges (SWOC) experience of histopathology image analysis, enhanced by artificial intelligence

Journal of Oral Biology and Craniofacial Research
Artificial intelligence (AI) is reshaping the landscape of oral cancer diagnosis through the analysis of digital imaging. By promoting early detection, enhancing diagnostic precision, and enabling personalised treatment approaches, AI holds the potential
Narendra Nath Singh, Ankita Tandon, Pavithra Jayasankar   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Enhancing diagnostic innovation by leveraging the co-creation approach

Journal of Pathology Informatics
Digital innovation in precision diagnostics requires addressing complex challenges, such as implementation, adoption, equity, and sustainability.
Jochen K. Lennerz, Alexandra Farfsing, Tim-Rasmus Kiehl, Sven Perner, Joost van Duuren, Marleen Christ, Jan W. Farfsing   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Strategic Entrepreneurship and Value Creation: A Comparative Case Study

, 2011
[[abstract]]This paper examines the relationship between strategic management and entrepreneurship and develops insights that advance the boundaries of the two fields and addresses an alternative strategic entrepreneurship framework.
Yee-Yeen Chu; Shih-Chang Hung　
core  

Creating corporate entrepreneurship through strategic leadership [PDF]

, 2008
The original publication is available at http://www.isma.info/index.php?k=6&s_id=9Strategy is not what it used to be. To compete effectively, large businesses must respond quickly, creatively and innovatively to develop an entrepreneurial environment ...
Scheepers, Retha, Hough, Johan, Scheepers, M J, Hough, J   +3 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source